| Portal hypertensive response to bradykinin in inflamed or cirrhotic rat livers is mediated by B2-type receptors. | |
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MedLine Citation:
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PMID: 11206315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We have shown that the portal hypertensive response to bradykinin in normal rats is mediated by B2 receptors. METHODS: By using isolated and exsanguinated rat liver perfusion, we studied the portal hypertensive response to bradykinin or des-Arg9-bradykinin (B1 agonist) in inflamed or cirrhotic rat livers. Livers were perfused with bovine serum albumin Krebs-Henseleit buffer (pH 7.4; 37 degrees C) at a constant flow rate, in the absence or presence of des-Arg9[Leu8]-bradykinin or HOE 140 (B1 and B2 receptor antagonists, respectively). Bradykinin (140 nmol) or des-Arg9-bradykinin was injected as a bolus via the afferent route to the liver. RESULTS: Basal perfusion pressure in liver-cirrhotic rats was higher than in normal rats. In normal, inflamed, or liver-cirrhotic rats, the presence of the B1 antagonist did not change the portal hypertensive response to bradykinin, while the B2 antagonist abolished this response. A 140-nmol dose of des-Arg9-bradykinin did not change the perfusion pressure; 700 nmol of this B1 agonist produced an insignificant perfusion pressure increase. The perfusion pressure increase induced by bradykinin in cirrhotic livers was lower than in normal livers. CONCLUSIONS: The portal hypertensive response to bradykinin in inflamed or cirrhotic rat livers is mediated by B2 receptors, but not B1 receptors, and there is a contracting hyporeactivity to bradykinin in cirrhotic rat livers. |
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Authors:
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M R Loureiro-Silva; H M Molina; D R Borges |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: 16 ISSN: 0815-9319 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-02-02 Completed Date: 2001-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: Australia |
Other Details:
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Languages: eng Pagination: 41-5 Citation Subset: IM |
Affiliation:
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Laboratory of Experimental Hepatology (Núcleo de Metabolismo Hepático), Universidade Federal de São Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Bradykinin / pharmacology* Carbon Tetrachloride Hypertension, Portal / drug therapy* Inflammation Kallidin / analogs & derivatives*, pharmacology* Liver Cirrhosis / chemically induced, metabolism*, pathology Male Rats Rats, Wistar Receptors, Bradykinin / metabolism* Turpentine |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Bradykinin; 342-10-9/Kallidin; 56-23-5/Carbon Tetrachloride; 58-82-2/Bradykinin; 71800-36-7/kallidin, des-Arg(10)-; 8006-64-2/Turpentine |
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