| Portal hypertensive enteropathy before and after variceal obliteration: an endoscopic, histopathologic and immunohistochemical study. | |
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MedLine Citation:
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PMID: 20593051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To study portal hypertensive enteropathy (PHE) before and after the obliteration of esophageal varices. METHODS: 30 patients with portal hypertension and esophageal varices were included. Band ligation was performed for every patient until the obliteration of esophageal varices. Enteroscopy and biopsies from gastric, duodenal and jejunal mucosa were taken at the beginning of the study and after variceal obliteration. Morphometric measurement of mean vascular areas and estimation of tissue vascular endothelial growth factor (VEGF) were also completed. RESULTS: The number of patients with enteropathy increased from 6.6% before obliteration to 46.7% after variceal obliteration (p< 0.001). Angiogenesis, vascular ectasia and blood extravasation were the main histopathological findings and all increased significantly after variceal obliteration. The mean vascular area of ectatic vessels in the gastric, duodenal and jejunal biopsies also increased after variceal obliteration. The mean VEGF in the gastric, duodenal and jejunal biopsies increased after variceal obliteration. The mean corpuscular volume (MCV) and hemoglobin (Hb) concentration were significantly lower after variceal obliteration. CONCLUSION: the portal hypertensive enteropathic changes increased in frequency and severity after esophageal variceal obliteration with a probability of causing anemia. |
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Authors:
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Hisham R El-Khayat; Ahmed El Khattib; Mona Nosseir; Mohamed Aboul Ezz; Hussein El-Amin; Yasser M Fouad |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of gastrointestinal and liver diseases : JGLD Volume: 19 ISSN: 1841-8724 ISO Abbreviation: J Gastrointestin Liver Dis Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-01 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101272825 Medline TA: J Gastrointestin Liver Dis Country: Romania |
Other Details:
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Languages: eng Pagination: 175-9 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Theodore Bilharz Institute, Cairo, Egypt. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia / etiology Biopsy Duodenum / pathology Egypt Endoscopy, Gastrointestinal* Esophageal and Gastric Varices / etiology, metabolism, pathology, surgery* Female Gastric Mucosa / pathology Gastrointestinal Hemorrhage / etiology, metabolism, pathology, surgery* Gastrointestinal Tract / blood supply, metabolism, pathology* Humans Hypertension, Portal / complications, metabolism, pathology, surgery* Immunohistochemistry* Intestinal Mucosa / pathology Jejunum / pathology Ligation Male Middle Aged Severity of Illness Index Treatment Outcome Vascular Endothelial Growth Factor A / analysis |
| Chemical | |
Reg. No./Substance:
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0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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