Document Detail


Portal hypertension and portal hypertensive gastropathy in patients with liver cirrhosis: a haemodynamic study.
MedLine Citation:
PMID:  12801039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIM: The relationships between the levels of portal hypertension and the morphologic alterations of gastric mucosa in patients with liver cirrhosis--generally described as portal hypertensive gastropathy--are poorly defined. PATIENTS: In total, 62 patients with cirrhosis of different aetiologies, were examined by endoscopy and measurement of portal hypertension by hepatic venous pressure gradient. RESULTS: Portal hypertensive gastropathy was observed in 49 cases; six patients showed gastric antral vascular ectasia always associated with gastric lesions described as severe portal hypertensive gastropathy with different localizations. Hepatic venous pressure gradient showed severe portal hypertension in 37 cases, and averaged 17.7 +/- 4.3 mmHg. It was much higher in patients with severe lesions (p=0.0004). Hepatic venous pressure gradient in patients with endoscopic signs of isolated antral gastropathy was lower (p=0.04) than in those with isolated lesions in body-fundus. No relationship was found between hepatic function, as assessed by the Child-Pugh score, and portal hypertensive gastropathy. CONCLUSIONS: The present data suggest that the severity of portal hypertensive gastropathy is related to portal hypertension, but portal hypertension is not the sole determinant of the occurrence of endoscopic abnormalities of gastric mucosa. The derangement of liver function does not appear to play any role in the occurrence of portal hypertensive gastropathy.
Authors:
C Merkel; M Schipilliti; R Bighin; B Bellini; P Angeli; M Bolognesi; F Vescovi; A Gatta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  35     ISSN:  1590-8658     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-06-12     Completed Date:  2003-07-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  269-74     Citation Subset:  IM    
Affiliation:
Department of Clinical and Experimental Medicine, University of Padua, Via Giustiniani, 2, 35128 Padua, Italy. carlo.merkel@unipd.it
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MeSH Terms
Descriptor/Qualifier:
Endoscopy, Digestive System
Gastric Antral Vascular Ectasia / physiopathology*
Gastric Mucosa / pathology
Hepatic Veins / physiopathology
Humans
Hypertension, Portal / physiopathology*
Liver Cirrhosis / physiopathology*
Middle Aged
Stomach Diseases / physiopathology*
Venous Pressure / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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