Document Detail

Portal hypertension in vinyl-chloride production workers.
MedLine Citation:
PMID:  61343     Owner:  NLM     Status:  MEDLINE    
Portal hypertension was seen in seven patients who had been involved in the production of vinyl-chloride monomer for 4-15 years. Four presented with bleeding oesophageal varices. In liver biopsy specimens non-cirrhotic portal fibrosis was inconspicuous and was seen more clearly on wedge rather than needle biopsy specimens. The intrahepatic venous pattern was hardly distrubed. Three patients have done well following shunt surgery. In one patient an angiosarcoma developed, but fibrosis was a more common lesion and was probably not pre-malignant.
P M Smith; I R Crossley; D M Williams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-11-21     Completed Date:  1976-11-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  602-4     Citation Subset:  AIM; IM    
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MeSH Terms
Chemical Industry
Esophageal and Gastric Varices / chemically induced
Gastrointestinal Hemorrhage / chemically induced
Hypertension, Portal / chemically induced*,  diagnosis,  physiopathology
Liver / physiopathology
Liver Function Tests
Middle Aged
Occupational Diseases / chemically induced*
Vinyl Chloride / adverse effects*
Vinyl Compounds / adverse effects*
Reg. No./Substance:
0/Vinyl Compounds; 75-01-4/Vinyl Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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