Document Detail

Portal hypertension: from bedside to bench.
MedLine Citation:
PMID:  15758647     Owner:  NLM     Status:  MEDLINE    
The initial factor leading to portal hypertension is an increase in hepatic resistance. Later, an increase in portal blood flow contributes to maintain and exacerbate portal hypertension despite the development of portosystemic collaterals. The critical step in the development and acceptance of these concepts, which proved crucial for the management of patients with portal hypertension, was the development of animal models. These allowed the full characterization of the profound hemodynamic abnormalities in the systemic and splanchnic circulation associated with portal hypertension, and the elucidation of the molecular mechanisms implicated in these disturbances. This review traces how seminal clinical observations in the 1950s raised meaningful questions that were subsequently answered at the bench, leading to our current understanding of the pathophysiology of portal hypertension and of the pathogenesis of severe complications of cirrhosis, such as variceal bleeding or ascites.
Roberto J Groszmann; Juan G Abraldes
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  39     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-10     Completed Date:  2005-07-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S125-30     Citation Subset:  IM    
Veterans Administration Medical Center, West Haven, CT 06516, USA.
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MeSH Terms
Hemodynamics / physiology
Hypertension, Portal / etiology*,  physiopathology
Liver Circulation / physiology
Liver Cirrhosis / physiopathology
Nitric Oxide / physiology
Portal System / physiology
Splanchnic Circulation / physiology
Vascular Resistance / physiology
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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