| Portal hypertension correlates with splenic stiffness as measured with MR elastography. | |
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MedLine Citation:
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PMID: 21608066 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the correlation between MR elastography (MRE) assessed spleen stiffness and direct portal vein pressure gradient (D-HVPG) measurements in a large animal model of portal hypertension. MATERIALS AND METHODS: Cholestatic liver disease was established in adult canines by common bile duct ligation. A spin echo based echo planar imaging (EPI) MRE sequence was used to acquire three-dimensional/three axis (3D/3-axis) abdominal MRE data at baseline, 4 weeks, and 8 weeks. Liver biopsies, blood samples, and D-HVPG measurements were obtained simultaneously. RESULTS: Animals developed portal hypertension (D-HVPG: 11.0 ± 5.1 mmHg) with only F1 fibrosis after 4 weeks. F3 fibrosis was confirmed after 8 weeks despite no further rise in portal hypertension (D-HVPG: 11.3 ± 3.2 mmHg). Mean stiffnesses of the spleen increased over two-fold from baseline (1.72 ± 0.33 kPa) to 4 weeks (3.54 ± 0.31 kPa), and stabilized at 8 weeks (3.38 ± 0.06 kPa) in a pattern consistent with changes in portal pressure. A positive correlation was observed between spleen stiffness and D-HVPG (r(2) = 0.86; P < 0.01). CONCLUSION: These findings indicate a temporal relationship between portal hypertension and the development of liver fibrosis in a large animal model of cholestatic liver disease. The observed direct correlation between spleen stiffness and D-HVPG suggest a noninvasive MRE approach to diagnose and screen for portal hypertension. |
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Authors:
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Geir I Nedredal; Meng Yin; Travis McKenzie; Joseph Lillegard; Jennifer Luebke-Wheeler; Jayant Talwalkar; Richard Ehman; Scott L Nyberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-05-23 |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 34 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-23 Completed Date: 2011-11-04 Revised Date: 2012-07-04 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 79-87 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Division of Transplantation Surgery, Department of Surgery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholestasis Disease Models, Animal Dogs Elasticity Imaging Techniques / methods* Fibrosis / diagnosis, pathology Humans Hypertension, Portal / diagnosis*, pathology* Liver / pathology Magnetic Resonance Imaging / methods* Pressure Regression Analysis Spleen / pathology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK056733-08/DK/NIDDK NIH HHS; R01 DK056733-08S1/DK/NIDDK NIH HHS; R01 DK056733-08S2/DK/NIDDK NIH HHS; R01 EB001981-13/EB/NIBIB NIH HHS; R01-DK56733/DK/NIDDK NIH HHS |
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