Document Detail

Portal hypertension correlates with splenic stiffness as measured with MR elastography.
MedLine Citation:
PMID:  21608066     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the correlation between MR elastography (MRE) assessed spleen stiffness and direct portal vein pressure gradient (D-HVPG) measurements in a large animal model of portal hypertension.
MATERIALS AND METHODS: Cholestatic liver disease was established in adult canines by common bile duct ligation. A spin echo based echo planar imaging (EPI) MRE sequence was used to acquire three-dimensional/three axis (3D/3-axis) abdominal MRE data at baseline, 4 weeks, and 8 weeks. Liver biopsies, blood samples, and D-HVPG measurements were obtained simultaneously.
RESULTS: Animals developed portal hypertension (D-HVPG: 11.0 ± 5.1 mmHg) with only F1 fibrosis after 4 weeks. F3 fibrosis was confirmed after 8 weeks despite no further rise in portal hypertension (D-HVPG: 11.3 ± 3.2 mmHg). Mean stiffnesses of the spleen increased over two-fold from baseline (1.72 ± 0.33 kPa) to 4 weeks (3.54 ± 0.31 kPa), and stabilized at 8 weeks (3.38 ± 0.06 kPa) in a pattern consistent with changes in portal pressure. A positive correlation was observed between spleen stiffness and D-HVPG (r(2) = 0.86; P < 0.01).
CONCLUSION: These findings indicate a temporal relationship between portal hypertension and the development of liver fibrosis in a large animal model of cholestatic liver disease. The observed direct correlation between spleen stiffness and D-HVPG suggest a noninvasive MRE approach to diagnose and screen for portal hypertension.
Geir I Nedredal; Meng Yin; Travis McKenzie; Joseph Lillegard; Jennifer Luebke-Wheeler; Jayant Talwalkar; Richard Ehman; Scott L Nyberg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-05-23
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  34     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-23     Completed Date:  2011-11-04     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-87     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
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MeSH Terms
Disease Models, Animal
Elasticity Imaging Techniques / methods*
Fibrosis / diagnosis,  pathology
Hypertension, Portal / diagnosis*,  pathology*
Liver / pathology
Magnetic Resonance Imaging / methods*
Regression Analysis
Spleen / pathology*
Time Factors
Grant Support
R01 DK056733/DK/NIDDK NIH HHS; R01 DK056733-08/DK/NIDDK NIH HHS; R01 DK056733-08S1/DK/NIDDK NIH HHS; R01 DK056733-08S2/DK/NIDDK NIH HHS; R01 EB001981/EB/NIBIB NIH HHS; R01-DK56733/DK/NIDDK NIH HHS

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