| Portal hemodynamics and clinical outcomes of patients with gastric varices after balloon-occluded retrograde transvenous obliteration. | |
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MedLine Citation:
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PMID: 20461439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Long-term hemodynamic effects and clinical outcomes after balloon-occluded retrograde transvenous obliteration (B-RTO) remain unclear. The purpose of this study was to evaluate long-term clinical results and effects on portal hemodynamics after B-RTO for the treatment of gastric varices with spontaneous gastrorenal shunt. METHODS: A total of 21 patients with cirrhosis and gastric varices treated by B-RTO were evaluated. The cumulative survival rate was calculated, portal blood flow was measured by Doppler ultrasonography, and liver function was estimated on the basis of Child-Pugh classification before and 1 year after B-RTO. RESULTS: Gastric varices disappeared or decreased markedly in size in all patients. Overall cumulative survival rates at 1, 3 and 5 years were 90.48, 71.11 and 53.71%, respectively. Portal blood flow increased significantly from 681.9 +/- 294.9 to 837.0 +/- 279.1 ml/min (P = 0.0125) after B-RTO. Child-Pugh score was not significantly changed (P = 0.755) after obliteration, but serum albumin was elevated significantly from 3.49 +/- 0.49 to 3.75 +/- 0.53 g/dl (P = 0.0459). The ascites score was significantly increased (P = 0.0455) after B-RTO, but all cases of ascites could be controlled with medication. CONCLUSIONS: Balloon-occluded retrograde transvenous obliteration is a safe and effective treatment for gastric varices with gastrorenal shunt. Portal blood flow and serum albumin parameters are increased, and liver function is unchanged after B-RTO. |
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Authors:
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Akiyoshi Kasuga; Hideaki Mizumoto; Shoichi Matsutani; Akitoshi Kobayashi; Tsunehiro Endo; Takeshi Ando; Seigo Yukisawa; Hitoshi Maruyama; Osamu Yokosuka |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-05-12 |
Journal Detail:
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Title: Journal of hepato-biliary-pancreatic sciences Volume: 17 ISSN: 1868-6982 ISO Abbreviation: J Hepatobiliary Pancreat Sci Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-08-24 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101528587 Medline TA: J Hepatobiliary Pancreat Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 898-903 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Funabashi Municipal Medical Center, Chiba, Japan. akiyoshi_81@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Balloon Occlusion / methods* Esophageal and Gastric Varices / mortality, physiopathology, therapy* Female Follow-Up Studies Humans Japan / epidemiology Male Middle Aged Portal System / physiopathology*, ultrasonography Regional Blood Flow / physiology* Retrospective Studies Survival Rate / trends Treatment Outcome Ultrasonography, Doppler, Color |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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