Document Detail


Portal fibroblasts: Underappreciated mediators of biliary fibrosis.
MedLine Citation:
PMID:  20209607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Portal fibroblasts are an important yet often overlooked nonparenchymal cell population in the liver. They are distinct from hepatic stellate cells, yet like stellate cells differentiate in the setting of chronic injury to fibrogenic myofibroblasts, playing an important role in collagen production in the fibrotic liver. Portal fibroblasts (PFs) are located adjacent to bile duct epithelia and thus play a particularly significant role in biliary fibrosis. New data suggest that they may also have key functions independent of fibrogenesis. This review addresses the definition and characteristics of PFs as well as their signaling pathways, interactions with the biliary epithelium, and contributions to liver pathobiology. Conclusion: PFs are an important and multifunctional nonparenchymal cell population in need of further study.
Authors:
Jonathan A Dranoff; Rebecca G Wells
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  51     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-07     Completed Date:  2010-04-21     Revised Date:  2013-06-13    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1438-44     Citation Subset:  IM    
Affiliation:
Section of Digestive Diseases, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA. jonathan.dranoff@yale.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Communication
Cell Differentiation
Fibroblasts / physiology*
Humans
Liver Cirrhosis, Biliary / etiology*
Portal System / pathology*
Signal Transduction
Grant Support
ID/Acronym/Agency:
DK34989/DK/NIDDK NIH HHS; P30 DK034989/DK/NIDDK NIH HHS; R01 DK058123-09S3/DK/NIDDK NIH HHS; R01 DK070849/DK/NIDDK NIH HHS; R01 DK58123/DK/NIDDK NIH HHS
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