| Portal fibroblasts: Underappreciated mediators of biliary fibrosis. | |
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MedLine Citation:
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PMID: 20209607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Portal fibroblasts are an important yet often overlooked nonparenchymal cell population in the liver. They are distinct from hepatic stellate cells, yet like stellate cells differentiate in the setting of chronic injury to fibrogenic myofibroblasts, playing an important role in collagen production in the fibrotic liver. Portal fibroblasts (PFs) are located adjacent to bile duct epithelia and thus play a particularly significant role in biliary fibrosis. New data suggest that they may also have key functions independent of fibrogenesis. This review addresses the definition and characteristics of PFs as well as their signaling pathways, interactions with the biliary epithelium, and contributions to liver pathobiology. Conclusion: PFs are an important and multifunctional nonparenchymal cell population in need of further study. |
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Authors:
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Jonathan A Dranoff; Rebecca G Wells |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 51 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-04-21 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
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Languages: eng Pagination: 1438-44 Citation Subset: IM |
Affiliation:
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Section of Digestive Diseases, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA. jonathan.dranoff@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Communication Cell Differentiation Fibroblasts / physiology* Humans Liver Cirrhosis, Biliary / etiology* Portal System / pathology* Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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DK34989/DK/NIDDK NIH HHS; R01 DK058123-09S3/DK/NIDDK NIH HHS; R01 DK070849/DK/NIDDK NIH HHS; R01 DK58123/DK/NIDDK NIH HHS |
| Comments/Corrections | |
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