Document Detail

Portal branch ligation in the rat. Reevaluation of a model.
MedLine Citation:
PMID:  3789089     Owner:  NLM     Status:  MEDLINE    
The effects of portal occlusion on the liver have been differently reported in different studies. The authors therefore reevaluated a model of portal branch ligation (PBL) in the rat. Histologic appearance, DNA synthetic activity, labeling count, and mitotic index were serially evaluated in both ligated and nonligated parts of the liver after interruption of the portal flow to one fourth, one third, and two thirds of the liver mass. The authors confirmed the presence of compensatory hyperplasia induced in the nonligated liver lobe(s) by PBL, and its intensity was roughly proportional to the amount of liver tissue devoid of portal perfusion. Portal-deprived liver tissue underwent a rapid and progressive atrophy, and, by the end of the first week, the weight of this part had decreased 10-fold. By a balance between atrophy and compensatory growth, the total liver weight was maintained at the level of sham-operated animals throughout the experiment. PBL invariably resulted in early centrilobular necrosis, which occupied 15-24% of the ligated lobe(s). However, already after 4 days it was almost totally resorbed and did not appear de novo. PBL was not followed by local collateralization.
J Rozga; B Jeppsson; S Bengmark
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of pathology     Volume:  125     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-12-24     Completed Date:  1986-12-24     Revised Date:  2010-09-10    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  300-8     Citation Subset:  AIM; IM    
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MeSH Terms
Liver / pathology*
Liver Circulation*
Portal System*
Rats, Inbred Strains
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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