Document Detail


Portal blood flow in cirrhosis of the liver.
MedLine Citation:
PMID:  6023778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Direct measurements of portal flow and pressure in a relatively large number of patients with cirrhosis show a marked reduction in flow associated with a nearly constant plateau of portal pressure. This lack of correlation indicates the complex relationships of resistances in the splanchnic, collateral, and hepatic circuits determining the division of the available splanchnic flow between the portal vein and the collateral pathways. Subtracting the measured portal flow from well-established estimates of total hepatic blood flow in cirrhosis suggests that the hepatic artery contributes more than one-half of the blood perfusing the cirrhotic liver. There was no instance of retrograde portal flow during the preshunt measurements, although such reversal was frequent after side-to-side portacaval anastomosis. Attempting to explain the plateau of portal pressure in the face of an increasing outflow resistance presumably associated with progress of the disease, we postulate that an augmented inflow resistance to the splanchnic chamber reduces splanchnic flow in cirrhosis. End-to-side portacaval anastomosis did not return normal portal flow, although it decreased pressure to accepted control levels. The assumption is that most of the splanchnic blood was flowing through the shunt, leading to a high splanchnic resistance in the immediate postshunt status. If this resistance was previously elevated, as suggested by the plateau of portal pressure, the mechanism responsible for the elevation was not immediately deactivated after the shunt, and the true effect of the operation upon splanchnic flow may not be measurable at such time. Respiratory oscillations were a significant component of portal flow in cirrhosis before and after portacaval anastomosis, indicating the limitations of any steady state analysis of the circulatory derangement in cirrhosis.
Authors:
A H Moreno; A R Burchell; L M Rousselot; W F Panke; F Slafsky; J H Burke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  46     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1967 Mar 
Date Detail:
Created Date:  1967-06-27     Completed Date:  1967-06-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  436-45     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure*
Blood Pressure Determination
Body Weight
Humans
Liver Circulation*
Liver Cirrhosis / physiopathology*
Portacaval Shunt, Surgical*
Portal System / physiopathology*
Regional Blood Flow
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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