| Portacaval shunting attenuates portal hypertension and systemic hypotension in rat anaphylactic shock. | |
| | |
MedLine Citation:
|
PMID: 21181324 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Anaphylactic shock in rats is characterized by antigen-induced hepatic venoconstriction and the resultant portal hypertension. We determined the role of portal hypertension in anaphylactic hypotension by using the side-to-side portacaval shunt- and sham-operated rats sensitized with ovalbumin (1 mg). We measured the mean arterial blood pressure (MAP), portal venous pressure (PVP), and central venous pressure (CVP) under pentobarbital anesthesia and spontaneous breathing. Anaphylactic hypotension was induced by an intravenous injection of ovalbumin (0.6 mg). In sham rats, the antigen caused not only an increase in PVP from 11.3 cmH(2)O to the peak of 27.9 cmH(2)O but also a decrease in MAP from 103 mmHg to the lowest value of 41 mmHg. CVP also decreased significantly after the antigen. In the portacaval shunt rats, in response to the antigen, PVP increased slightly, but significantly, to the peak of 17.5 cmH(2)O, CVP did not decrease, and MAP decreased to a lesser degree with the lowest value being 60 mmHg. These results suggest that the portacaval shunt attenuated anaphylactic portal hypertension and venous return decrease, partially preventing anaphylactic hypotension. In conclusion, portal hypertension is involved in rat anaphylactic hypotension presumably via splanchnic congestion resulting in decreased venous return and thus systemic arterial hypotension. |
| | |
Authors:
|
Chiaki Kamikado; Toshishige Shibamoto; Wei Zhang; Yuhichi Kuda; Chieko Ohmukai; Yasutaka Kurata |
Related Documents
:
|
21514044 - Temperature and pressure influence on maximum rates of pressure rise during explosions ... 21525564 - The donnan equilibrium: i. on the thermodynamic foundation of the donnan equation of st... 21218324 - Multiple emg activity and intracortical inhibition and facilitation during a fine finge... 21339584 - A high pressure ca-vi phase between 158 and 180 gpa: stability, electronic structure an... 22248104 - Evaluation of esophageal contractile propagation using esophageal pressure topography. 23571074 - Safety climate dimensions as predictors for risk behavior. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2010-12-22 |
Journal Detail:
|
Title: The journal of physiological sciences : JPS Volume: - ISSN: 1880-6562 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101262417 Medline TA: J Physiol Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Physiology II, Kanazawa Medical University, Uchinada Ishikawa, 920-0293, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A mathematical model for lactate transport to red blood cells.
Next Document: Population based study to assess prevalence and risk factors of gastroesophageal reflux disease in a...