Document Detail

Portable ceria nanoparticle-based assay for rapid detection of food antioxidants (NanoCerac).
MedLine Citation:
PMID:  23139929     Owner:  NLM     Status:  MEDLINE    
With increased awareness of nutrition and the advocacy for healthier food choices, there exists a great demand for a simple, easy-to-use test that can reliably measure the antioxidant capacity of dietary products. We report development and characterization of a portable nanoparticle based-assay, similar to a small sensor patch, for rapid and sensitive detection of food antioxidants. The assay is based on the use of immobilized ceria nanoparticles, which change color after interaction with antioxidants by means of redox and surface chemistry reactions. Monitoring corresponding optical changes enables sensitive detection of antioxidants in which the nanoceria provides an optical 'signature' of antioxidant power, while the antioxidants act as reducing agents. The sensor has been tested for the detection of common antioxidant compounds including ascorbic acid, gallic acid, vanillic acid, quercetin, caffeic acid, and epigallocatechin gallate and its function has been successfully applied for the assessment of antioxidant activity in real samples (teas and medicinal mushrooms). The colorimetric response was concentration dependent, with detection limits ranging from 20 to 400 μM depending on the antioxidant involved. Steady-state color intensity was achieved within seconds upon addition of antioxidants. The results are presented in terms of Gallic Acid Equivalents (GAE). The sensor performed favorably when compared with commonly used antioxidant detection methods. This assay is particularly appealing for remote sensing applications, where specialized equipment is not available, and also for high throughput analysis of a large number of samples. Potential applications for antioxidant detection in remote locations are envisioned.
Erica Sharpe; Thalia Frasco; Daniel Andreescu; Silvana Andreescu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-09
Journal Detail:
Title:  The Analyst     Volume:  138     ISSN:  1364-5528     ISO Abbreviation:  Analyst     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-28     Completed Date:  2014-01-08     Revised Date:  2014-01-16    
Medline Journal Info:
Nlm Unique ID:  0372652     Medline TA:  Analyst     Country:  England    
Other Details:
Languages:  eng     Pagination:  249-62     Citation Subset:  IM    
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MeSH Terms
Antioxidants / analysis*,  chemistry
Camellia sinensis / chemistry
Cerium / chemistry*
Food Analysis / methods*
Metal Nanoparticles / chemistry*
Plants, Medicinal / chemistry
Reproducibility of Results
Spectrum Analysis
Time Factors
Grant Support
Reg. No./Substance:
0/Antioxidants; 30K4522N6T/Cerium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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