Document Detail

Porphyromonas gingivalis in periodontal pockets and heart valves.
MedLine Citation:
PMID:  24705065     Owner:  NLM     Status:  Publisher    
Background There is evidence that advanced infectious chronic periodontal inflammatory disease may have an impact on general health including cardiovascular diseases. The aim of this clinical study was to evaluate the ability of Porphyromonas gingivalis to colonize heart valves and, subsequently, to assess whether there is an association between the presence of the DNA of Porphyromonas gingivalis in periodontal pockets and in degenerated heart valves. Materials and Methods Thirty patients were enrolled in the study and 30 one valve specimens harvested during cardiac surgery operations were examined. All patients underwent a periodontal examination. To evaluate the periodontal status of the patients the following clinical parameters were recorded: the pocket depth, bleeding on probing (BOP) and aproximal plaque index (API). The presence of P. gingivalis in heart valve specimens and samples from periodontal pockets was analyzed using a single-step PCR method. Results P. gingivalis DNA was detected in periodontal pockets of 15 patients (50%). However, the DNA of this periopathogen was found neither in the aortic nor in the mitral valve specimens. Conclusions This study suggests that P. gingivalis may not have an influence on the development of the degeneration of aortic and mitral valves.
Małgorzata Radwan-Oczko; Aleksander Jaworski; Irena Duś; Tomasz Plonek; Malgorzata Szulc; Wojciech Kustrzycki
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-04
Journal Detail:
Title:  Virulence     Volume:  5     ISSN:  2150-5608     ISO Abbreviation:  Virulence     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101531386     Medline TA:  Virulence     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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