Document Detail


Porphyromonas gingivalis in dental plaque and serum C-reactive protein levels in pregnancy.
MedLine Citation:
PMID:  20601787     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The periodontopathogen Porphyromonas gingivalis (Pg) has been reported as a risk factor for preterm labour. Its pathogenesis and role in pregnancy have not been investigated in Lebanon. Elevated C-reactive protein (CRP) levels in pregnant women with periodontitis also appear to mediate preterm labour. METHODOLOGY: The study included 20 pregnant women with periodontitis and 20 with normal periodontium. PCR was done for Pg detection in oral plaque and vaginal samples. Serum CRP levels were determined by ELISA. RESULTS: Pg was detected in the oral plaque of 13 of 20 pregnant subjects with clinical periodontitis (patients) and 2 of 20 controls with a healthy periodontium. Vaginal swabs were all Pg-negative, ruling out systemic infection. Serum CRP levels were elevated in 12 of 20 patients and 8 of 20 controls. None of the participants experienced preterm labour. CONCLUSIONS: This is the first report that implicates Pg in Lebanese periodontitis patients. Preliminary results do not indicate a relationship among Pg, periodontitis, CRP levels and preterm labour.
Authors:
Nada M Souccar; Marita Chakhtoura; Joseph G Ghafari; Alexander Michael Abdelnoor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-30
Journal Detail:
Title:  Journal of infection in developing countries     Volume:  4     ISSN:  1972-2680     ISO Abbreviation:  J Infect Dev Ctries     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-05     Completed Date:  2010-10-07     Revised Date:  2010-11-15    
Medline Journal Info:
Nlm Unique ID:  101305410     Medline TA:  J Infect Dev Ctries     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  362-6     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, Faculty of Medicine, American University of Beirut, Beirut 1107 2020, Lebanon.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bacteroidaceae Infections / epidemiology*,  microbiology
C-Reactive Protein / analysis*
Dental Plaque / microbiology*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Lebanon / epidemiology
Periodontitis / epidemiology*,  microbiology
Polymerase Chain Reaction
Porphyromonas gingivalis / isolation & purification*
Pregnancy
Pregnancy Complications, Infectious / epidemiology*
Serum / chemistry
Vagina / microbiology
Young Adult
Chemical
Reg. No./Substance:
9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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