Document Detail

Porphyrin concentrations in various human tissues.
MedLine Citation:
PMID:  8535617     Owner:  NLM     Status:  MEDLINE    
We measured the concentrations of total porphyrins and their metabolites (uro-, hepta-, hexa-, penta-, copro- and protoporphyrin) in various human tissues: liver, erythrocytes, skin, adipose tissue, and mammary gland. The porphyrin concentrations varied within major limits, e.g., 3.1 +/- 2.3 nmol porphyrins/g liver and 0.50 +/- 0.10 nmol/g erythrocytes. No significant differences were detectable in other tissues in comparison with liver. In all tissues, the predominant metabolite was protoporphyrin, followed by coproporphyrin, whereas only low concentrations of higher carboxylated porphyrins such as uroporphyrin were detectable. It is concluded that porphyrin metabolism and its regulation is similar in all human tissues, perhaps with some small differences in the erythrocytes.
G Goerz; A Link-Mannhardt; K Bolsen; M Zumdick; C Fritsch; N Y Schürer
Related Documents :
19948207 - The autocrine and paracrine roles of adipokines.
19013497 - Dhea metabolism in prostate: for better or worse?
15232707 - Depression of transcription and translation during daily torpor in the djungarian hamst...
6634837 - 31-p nmr in the study of liver metabolism in vivo.
24335437 - β3-adrenoceptor mediates metabolic protein remodeling in a rabbit model of tachypacing...
6333137 - On some presynaptic effects of meramyzole (analgine-pharmachim).
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Experimental dermatology     Volume:  4     ISSN:  0906-6705     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-02-08     Completed Date:  1996-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  218-20     Citation Subset:  IM    
Department of Dermatology, University of Düsseldorf, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adipose Tissue / chemistry*
Breast / chemistry*
Erythrocytes / chemistry*
Liver / chemistry*
Porphyrins / analysis*
Skin / chemistry*
Tissue Distribution
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Contact sensitizers modulate mechanisms of receptor-mediated endocytosis but not fluid-phase endocyt...
Next Document:  Endoscopic ultrasonography diagnosis of pancreatic cancer.