Document Detail


Porphyrin concentrations in various human tissues.
MedLine Citation:
PMID:  8535617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We measured the concentrations of total porphyrins and their metabolites (uro-, hepta-, hexa-, penta-, copro- and protoporphyrin) in various human tissues: liver, erythrocytes, skin, adipose tissue, and mammary gland. The porphyrin concentrations varied within major limits, e.g., 3.1 +/- 2.3 nmol porphyrins/g liver and 0.50 +/- 0.10 nmol/g erythrocytes. No significant differences were detectable in other tissues in comparison with liver. In all tissues, the predominant metabolite was protoporphyrin, followed by coproporphyrin, whereas only low concentrations of higher carboxylated porphyrins such as uroporphyrin were detectable. It is concluded that porphyrin metabolism and its regulation is similar in all human tissues, perhaps with some small differences in the erythrocytes.
Authors:
G Goerz; A Link-Mannhardt; K Bolsen; M Zumdick; C Fritsch; N Y Schürer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Experimental dermatology     Volume:  4     ISSN:  0906-6705     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-02-08     Completed Date:  1996-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  218-20     Citation Subset:  IM    
Affiliation:
Department of Dermatology, University of Düsseldorf, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / chemistry*
Breast / chemistry*
Erythrocytes / chemistry*
Female
Humans
Liver / chemistry*
Porphyrins / analysis*
Skin / chemistry*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Porphyrins

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