Document Detail


Porphyric polyneuropathy and its pathogenesis in the light of electrophysiological investigations.
MedLine Citation:
PMID:  632833     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-four patients with acute intermittent porphyria were examined by means of routine electromyographic (EMG) tests, measurements of motor and sensory conduction in peripheral nerves and stimulation fatigue tests. The EMG results gave evidence of an initial, reversible disorder of function of the peripheral neuron, only sometimes followed by evidence of axonal degeneration of the "dying back" type. In stimulation fatigue tests there was some evidence of potentiation but none of fatigue. Attention is drawn to some analogies between the electrophysiological changes in porphyric polyneuropathy and in botulism. It seems that the pathogenesis of porphyric polyneuropathy may be dependent upon a block of cholinergic endings.
Authors:
D Wochnik-Dyjas; M Niewiadomska; E Kostrzewska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  35     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-05-17     Completed Date:  1978-05-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  243-56     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Electromyography
Evoked Potentials
Exercise Test
Humans
Median Nerve / physiopathology
Motor Neurons / physiology
Muscle Contraction
Muscles / physiopathology
Nerve Degeneration
Neural Conduction
Polyneuropathies / physiopathology*
Porphyrias / complications*
Sural Nerve / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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