| PORPHOBILINOGEN AND DELTA-AMINOLEVULINIC ACID EXCRETION IN MULTIPLE SCLEROSIS. | |
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MedLine Citation:
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PMID: 14312444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The excretion of delta-aminolevulinic acid and porphobilinogen in the urine of 31 patients with multiple sclerosis did not differ significantly from that of 51 hospitalized control patients or eight patients with poliomyelitis. There was no relationship between exacerbations, remissions or duration of the illness, and levels of delta-aminolevulinic acid or of porphobilinogen. These assays therefore appear to be of no value in the differential diagnosis of multiple sclerosis or in following the severity or stage of this illness. Whereas demyelination does occur in acute porphyria where the levels of delta-aminolevulinic acid and porphobilinogen are elevated, the converse is not true; that is, demyelination is not always associated with an increase in the excretion of porphobilinogen or delta-aminolevulinic acid. |
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Authors:
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J D TAYLOR; L H PAZDER; V MARKLE |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian Medical Association journal Volume: 92 ISSN: 0008-4409 ISO Abbreviation: Can Med Assoc J Publication Date: 1965 Jun |
Date Detail:
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Created Date: 1965-10-01 Completed Date: 1996-12-01 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 0414110 Medline TA: Can Med Assoc J Country: CANADA |
Other Details:
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Languages: eng Pagination: 1342-4 Citation Subset: OM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids* Demyelinating Diseases* Diagnosis, Differential* Fluids and Secretions* Levulinic Acids Multiple Sclerosis* Poliomyelitis* Porphyrias* Porphyrins* Pyrroles* Urine* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Levulinic Acids; 0/Porphyrins; 0/Pyrroles; 123-76-2/levulinic acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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