Document Detail

Pork peptone stimulates cholecystokinin secretion from enteroendocrine cells and suppresses appetite in rats.
MedLine Citation:
PMID:  16926499     Owner:  NLM     Status:  MEDLINE    
We found that soybean beta-conglycinin peptone (BconP) suppresses food intake through cholecystokinin (CCK) release from enteroendocrine cells in association with binding of the peptone to rat small intestinal brush border membrane (BBM). The aim of the present study was to find new appetite suppressing peptides. Peptones from chicken, pork, beef, beef liver, and egg white were examined for activities to bind with rat BBM, CCK-release from enteroendocrine cell line STC-1, and induce satiety in rats. Chicken and pork peptone (ChickP and PorkP) bound to BBM with highest ability as evaluated with a surface plasmon biosensor. PorkP and ChickP released CCK in higher amounts than BconP from STC-1 cells dose-dependently, with highest stimulation by PorkP. An orogastric preload of PorkP, but not ChickP, suppressed food intake similarly to BconP, dose-dependently. These results suggest that PorkP interacts directly with the small intestinal CCK cells to release CCK, and that it suppresses appetite in rats.
M K N B Sufian; Tohru Hira; Kyoko Miyashita; Takashi Nishi; Kozo Asano; Hiroshi Hara
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  70     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-23     Completed Date:  2006-11-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1869-74     Citation Subset:  IM    
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan.
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MeSH Terms
Appetite / drug effects*
Cholecystokinin / drug effects,  metabolism,  secretion*
Dose-Response Relationship, Drug
Enteroendocrine Cells / chemistry,  drug effects*
Intestine, Small / cytology,  drug effects,  metabolism
Peptones / administration & dosage,  metabolism,  pharmacology*
Protein Binding
Rats, Sprague-Dawley
Species Specificity
Reg. No./Substance:
0/Peptones; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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