Document Detail


Pore size distribution in tablets measured with a morphological sieve.
MedLine Citation:
PMID:  17580106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Porosity and pore structure are important characteristics of tablets, since they influence mechanical strength and many other properties. This paper proposes an alternative method for the characterization of pore structure based on image analysis of SEM micrographs. SEM images were made of sodium chloride tablets made with three different particle sizes. The pore size distribution in these images was determined with a technique referred to as a morphological sieve. The results were compared to the pore size distributions as obtained with mercury porosimetry. The SEM images display small cracks inside the grains and small 'floating' grains inside the pore space. As these artifacts are induced in sample preparation, they need to be identified and removed from the images before analysis. The influence of the size of the discarded structures on the total porosity and the pore size distribution was investigated. The small 'floating' grains prevented the determination of the size of large pores, but had a negligible effect on the porosity. The removal of small cracks inside the grains had no effect on the pore size distribution but a large effect on the porosity. Based on the comparison of these results with the experimentally determined porosity, a maximum size for the structures that were to be removed was determined. The resulting pore size distributions were in the same order of magnitude as the results obtained with mercury porosimetry. Both methods display a comparable relative shift of the pore size distributions to larger sizes for tablets with increasing particle size. Therefore, it can be concluded this image analysis technique is a good method for the characterization of pore structure.
Authors:
Yu San Wu; Lucas J van Vliet; Henderik W Frijlink; Kees van der Voort Maarschalk
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Publication Detail:
Type:  Journal Article     Date:  2007-05-16
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  342     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-21     Completed Date:  2007-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  176-83     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands. y.s.wu@rug.nl
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Chromatography, Gel
Image Processing, Computer-Assisted
Mercury / chemistry
Microscopy, Electron, Scanning
Particle Size
Porosity
Powders
Sodium Chloride / chemistry
Tablets / chemistry*
Chemical
Reg. No./Substance:
0/Powders; 0/Tablets; 7439-97-6/Mercury; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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