Document Detail


Porcine small intestine submucosa xenograft augmentation in repair of massive rotator cuff tears.
MedLine Citation:
PMID:  20049352     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this prospective study, we evaluated the efficacy of using porcine small intestine submucosa (SIS) xenograft to augment the repair of massive rotator cuff tears. Our hypothesis was that SIS xenograft would help restore tendon tissue in the human model, as has been shown in several animal studies. Eleven patients were followed clinically for a mean of 26 months (range, 14-38 months). Mean University of California Los Angeles end-result scores improved from 13.9 before surgery to 25.7 after surgery, American Shoulder and Elbow Surgeons scores improved from 36.3 to 71.8, and the visual analog scale pain score decreased from 6.6 to 2.0. All findings were statistically significant (P<.01). At a mean of 25 months after surgery, magnetic resonance arthrography (MRA) showed the repairs partially or completely intact in 44% of shoulders. Intact repairs were thin and wispy. There were 3 complications, which included 1 infection and 2 localized skin reactions that resolved spontaneously. SIS xenograft did not reconstitute rotator cuff tissue or add to the quality of the rotator cuff repair. Given clinical concerns about localized reactions in this series and suboptimal MRA findings, use of SIS xenograft to augment rotator cuff repairs is not recommended.
Authors:
Wesley P Phipatanakul; Steve A Petersen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of orthopedics (Belle Mead, N.J.)     Volume:  38     ISSN:  1934-3418     ISO Abbreviation:  Am J. Orthop.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-01-05     Completed Date:  2010-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502918     Medline TA:  Am J Orthop (Belle Mead NJ)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  572-5     Citation Subset:  IM    
Affiliation:
Department of Orthopaedic Surgery, Loma Linda University, Loma Linda, CA 92354, USA. wphip@hotmail.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Arthroscopy
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Orthopedic Procedures / methods
Pain Measurement
Prospective Studies
Range of Motion, Articular
Rotator Cuff / injuries*,  surgery*
Swine
Tendon Injuries / surgery*
Transplantation, Heterologous
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Atrophic nonunion of humeral diaphysis treated with locking plate and recombinant bone morphogenetic...
Next Document:  Effects of recombinant human bone morphogenetic protein 2 on surgical infections in a rabbit postero...