Document Detail


Porcine defibrillation thresholds with chopped biphasic truncated exponential waveforms.
MedLine Citation:
PMID:  17383792     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Conventional biphasic truncated exponential (BTE) waveforms have been studied extensively but less is known about "chopping modulated" BTE shocks. Previous studies comparing chopped and unchopped waveforms have found conflicting results. This study compared the defibrillation thresholds (DFTs) of a variety of chopped and unchopped BTE waveforms. METHODS: Six anesthetized pigs were defibrillated after 15s of electrically induced ventricular fibrillation (VF). Three waveform types were studied: unchopped BTE, "short" duration chopped, and "long" duration chopped waveforms. Each type included waveforms generated with 50, 100, and 200 microF capacitances, giving 9 total waveforms. Shocks were delivered in a standard up-down protocol and the order of the waveforms was randomized. Defibrillation thresholds were calculated using a Bayesian logistic regression model. RESULTS: DFTs of the 50, 100, and 200 microF unchopped waveforms were 122+/-22, 124+/-22, and 126+/-22 J. Short chopped DFTs were at least 75+/-23 J higher than unchopped DFTs. Long chopped DFTs averaged 66+/-20 J more than short chopped DFTs. There is a 99.5% probability that the best of the chopped waveforms has a higher DFT than the worst of the unchopped waveforms, and a 95% probability that the difference is at least 37 J. DFT differences between capacitor values were less than 7 J for all waveform types. CONCLUSIONS: When treating swine with short-duration VF, chopped waveforms require more energy to defibrillate than unchopped waveforms. More study is required to assess the performance of chopped waveforms when treating cardiac arrest patients.
Authors:
Joseph L Sullivan; Sharon B Melnick; Fred W Chapman; Gregory P Walcott
Publication Detail:
Type:  Journal Article     Date:  2007-03-26
Journal Detail:
Title:  Resuscitation     Volume:  74     ISSN:  0300-9572     ISO Abbreviation:  Resuscitation     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-10     Completed Date:  2007-11-08     Revised Date:  2009-08-25    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  325-31     Citation Subset:  IM    
Affiliation:
Medtronic Emergency Response Systems, 11811 Willows Rd NE, P.O. Box 97006, Redmond, WA 98073-9706, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bayes Theorem
Electric Countershock*
Signal Processing, Computer-Assisted
Swine
Ventricular Fibrillation / physiopathology*,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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