Document Detail

Porcine alpha-1-antitrypsin (PI): cDNA sequence, polymorphism and assignment to chromosome 7q2.4- > q2.6.
MedLine Citation:
PMID:  8856896     Owner:  NLM     Status:  MEDLINE    
A cDNA clone encoding the complete coding sequence for porcine alpha-1-antitrypsin (or alpha 1-protease inhibitor, PI) was isolated and its DNA sequence determined. The cDNA is assumed to encode alpha-1-antitrypsin on the basis of its sequence similarity to the corresponding cDNAs for human, baboon, rat, mouse, sheep and cow. The porcine cDNA clone was used in conjunction with BamHI, KpnI, MspI, SacI, TaqI and XbaI to develop restriction fragment length polymorphism-based genetic markers for linkage mapping in pigs. The cDNA has also been used to map the porcine PI locus to chromosome 7q2.4- > q2.6 by radioactive in situ hybridization. Thus, the PI locus has been added to the developing physical and genetic maps of the porcine genome.
A L Archibald; S Couperwhite; C H Mellink; Y Lahbib-Mansais; J Gellin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Animal genetics     Volume:  27     ISSN:  0268-9146     ISO Abbreviation:  Anim. Genet.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-11-19     Completed Date:  1996-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8605704     Medline TA:  Anim Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  85-9     Citation Subset:  IM    
Roslin Institute (Edinburgh), Midlothian, UK.
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MeSH Terms
Chromosome Mapping*
Cloning, Molecular
DNA, Complementary / genetics*
Molecular Sequence Data
Polymorphism, Restriction Fragment Length*
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Swine / genetics*
alpha 1-Antitrypsin / genetics*
Reg. No./Substance:
0/DNA, Complementary; 0/alpha 1-Antitrypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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