Document Detail


Porcine Toll-like receptors: Recognition of Salmonella enterica serovar Choleraesuis and influence of polymorphisms.
MedLine Citation:
PMID:  21388684     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Salmonella enterica serovar Choleraesuis (SC) is a highly invasive pathogen that causes enteric and septicemic diseases in pigs. Although there have been some reports on gene expression profiles in the course of infection with SC in pigs, little is known about the genes involved in the infection. By measuring activation, as represented by nuclear factor-κB activity, after stimulation by the pathogen, we showed the involvement of Toll-like receptor (TLR) 5 and the TLR2-TLR1 heterodimer in the recognition of SC. We previously found single nucleotide polymorphisms (SNPs) in the TLRs of various pig populations. Here we demonstrated that the polymorphisms resulting in amino acid changes TLR5(R148L), TLR5(P402L), and TLR2(V703M) attenuated the responses to SC by the cells transfected with the TLR genes. Each of these three SNPs was differently restricted in distribution among breeds. These results suggest that there are differences in resistance to salmonellosis among breeds; these differences may be of great importance for the pig industry in terms of breeding and vaccine development.
Authors:
Hiroki Shinkai; Rintaro Suzuki; Masato Akiba; Naohiko Okumura; Hirohide Uenishi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-7
Journal Detail:
Title:  Molecular immunology     Volume:  -     ISSN:  1872-9142     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905289     Medline TA:  Mol Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Division of Animal Sciences, National Institute of Agrobiological Sciences (NIAS), 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8602, Japan; Animal Genome Research Program, NIAS/STAFF, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8602, Japan.
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