Document Detail

Population subdivision and the detection of recombination in non-typable Haemophilus influenzae.
MedLine Citation:
PMID:  23038806     Owner:  NLM     Status:  MEDLINE    
The disparity in diversity between unencapsulated (non-typable; NT) and encapsulated, serotypable Haemophilus influenzae (Hi) has been recognized for some time. It has previously been suggested that the wider diversity evidenced within NTHi compared with typable lineages may be due to different rates of recombination within the encapsulated and NT populations. To examine whether there is evidence for different levels of recombination within typable and NT lineages of Hi, we performed a statistical genetic analysis of 819 distinct genotypes of Hi to explore the congruence of serotype with population genetic clustering, and to identify patterns of recombination within the Hi population. We find that a significantly larger proportion of NT isolates show evidence of recombination, compared with typable isolates, and also that when admixture is present, the total amount of recombination per strain is greater within NT isolates, compared with the typable population. Furthermore, we demonstrate significant heterogeneity in the number of admixed individuals between NT lineages themselves, while such variation was not observed in typable lineages. This variability suggests that factors other than the presence of capsule are important determinants of recombination rate in the Hi population.
Thomas Richard Connor; Jukka Corander; William Paul Hanage
Related Documents :
22961556 - Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty l...
23438326 - Polymorphisms in gabrb3 and oral clefting in the brazilian population.
954226 - Human chromosome polymorphism and congenital malformations.
23822756 - Gene variants associated with antisocial behaviour: a latent variable approach.
10695056 - Applications of molecular genotyping to immunohaematology.
19646406 - Codon stabilization analysis of the "248" temperature sensitive mutation for increased ...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-04
Journal Detail:
Title:  Microbiology (Reading, England)     Volume:  158     ISSN:  1465-2080     ISO Abbreviation:  Microbiology (Reading, Engl.)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-05-02     Revised Date:  2014-08-06    
Medline Journal Info:
Nlm Unique ID:  9430468     Medline TA:  Microbiology     Country:  England    
Other Details:
Languages:  eng     Pagination:  2958-64     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cluster Analysis
Genetic Variation*
Haemophilus influenzae / classification*,  genetics*
Multilocus Sequence Typing
Recombination, Genetic*
Grant Support
098051//Wellcome Trust; GM088558-01/GM/NIGMS NIH HHS; U54 GM088558/GM/NIGMS NIH HHS; //Biotechnology and Biological Sciences Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  MaHog1, a Hog1-type MAP kinase gene, contributes to stress tolerance and virulence of the entomopath...
Next Document:  The two-component system ChrSA is crucial for heme tolerance and interferes with HrrSA in heme-depen...