Document Detail

Population subdivision and the detection of recombination in non-typable Haemophilus influenzae.
MedLine Citation:
PMID:  23038806     Owner:  NLM     Status:  Publisher    
The disparity in diversity between unencapsulated (Non Typable, NT) and encapsulated, serotypable Haemophilus influenzae (Hi) has been recognised for some time. It has previously been suggested that the wider diversity evidenced within NT Hi compared with typable lineages may be due to different rates of recombination within the encapsulated and NT populations. To examine if there is evidence for different levels of recombination within typable and NT lineages of Hi, we performed a statistical genetic analysis of 819 distinct genotypes of Hi to explore the congruence of serotype with population genetic clustering, and to identify patterns of recombination within the Hi population. We find that a significantly larger proportion of NT isolates show evidence of recombination, compared with typable isolates, and also that when admixture is present, the total amount of recombination per strain is greater within NT isolates, compared with the typable population. Furthermore we demonstrate significant heterogeneity in the number of admixed individuals between NT lineages themselves, while such variation was not observed in typable lineages. This variability suggests that factors other than the presence of capsule are important determinants of recombination rate in the Hi population.
Thomas Richard Connor; Jukka Corander; William Paul Hanage
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  Microbiology (Reading, England)     Volume:  -     ISSN:  1465-2080     ISO Abbreviation:  Microbiology (Reading, Engl.)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430468     Medline TA:  Microbiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Wellcome Trust Sanger Institute;
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