| Population pharmacokinetics of teicoplanin in patients with endocarditis. | |
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MedLine Citation:
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PMID: 8576842 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Teicoplanin is a new glycopeptide antibiotic, active against aerobic and anaerobic gram-positive bacteria. The drug is intended for the treatment of systemic infections including endocarditis. In two U.S. clinical safety and efficacy trials, loading doses of 6 to 30 mg/kg doses of teicoplanin were administered initially to 197 patients, followed by once-a-day treatment of approximately the same doses over several weeks. Blood samples were collected sporadically during the study to monitor serum teicoplanin concentrations either by FPIA or microbiological assay. Nonlinear mixed-effects modeling was performed on these data to characterize the population pharmacokinetics of teicoplanin that were best described by a two-compartment model. Patient body weight, concomitant gram-positive drug treatment, and serum creatinine had significant influences on systemic clearance (CL) of the glycopeptide. In addition, body weight affected the volume of distribution of the central compartment (Vc). Other demographic factors such as age, gender, etc., had no effects. The FPIA assay method was more precise than the microbiological assay. |
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Authors:
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D K Yu; E Nordbrock; S J Hutcheson; E W Lewis; W Sullivan; V O Bhargava; S J Weir |
Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of pharmacokinetics and biopharmaceutics Volume: 23 ISSN: 0090-466X ISO Abbreviation: J Pharmacokinet Biopharm Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1996-03-11 Completed Date: 1996-03-11 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0357115 Medline TA: J Pharmacokinet Biopharm Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 25-39 Citation Subset: IM |
Affiliation:
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U.S. Pharmacokinetics Department, Hoechst Marion Roussel, Inc., Kansas City, Missouri 64137, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents / pharmacokinetics* Double-Blind Method Endocarditis, Bacterial / drug therapy, metabolism* Female Humans Male Middle Aged Models, Biological Teicoplanin / pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 61036-62-2/Teicoplanin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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