Document Detail


Population pharmacokinetics of teicoplanin in patients with endocarditis.
MedLine Citation:
PMID:  8576842     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Teicoplanin is a new glycopeptide antibiotic, active against aerobic and anaerobic gram-positive bacteria. The drug is intended for the treatment of systemic infections including endocarditis. In two U.S. clinical safety and efficacy trials, loading doses of 6 to 30 mg/kg doses of teicoplanin were administered initially to 197 patients, followed by once-a-day treatment of approximately the same doses over several weeks. Blood samples were collected sporadically during the study to monitor serum teicoplanin concentrations either by FPIA or microbiological assay. Nonlinear mixed-effects modeling was performed on these data to characterize the population pharmacokinetics of teicoplanin that were best described by a two-compartment model. Patient body weight, concomitant gram-positive drug treatment, and serum creatinine had significant influences on systemic clearance (CL) of the glycopeptide. In addition, body weight affected the volume of distribution of the central compartment (Vc). Other demographic factors such as age, gender, etc., had no effects. The FPIA assay method was more precise than the microbiological assay.
Authors:
D K Yu; E Nordbrock; S J Hutcheson; E W Lewis; W Sullivan; V O Bhargava; S J Weir
Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of pharmacokinetics and biopharmaceutics     Volume:  23     ISSN:  0090-466X     ISO Abbreviation:  J Pharmacokinet Biopharm     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1996-03-11     Completed Date:  1996-03-11     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0357115     Medline TA:  J Pharmacokinet Biopharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  25-39     Citation Subset:  IM    
Affiliation:
U.S. Pharmacokinetics Department, Hoechst Marion Roussel, Inc., Kansas City, Missouri 64137, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / pharmacokinetics*
Double-Blind Method
Endocarditis, Bacterial / drug therapy,  metabolism*
Female
Humans
Male
Middle Aged
Models, Biological
Teicoplanin / pharmacokinetics*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 61036-62-2/Teicoplanin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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