Document Detail

Population growth kinetics and bulk membrane lipid alterations in Tetrahymena pyriformis: exposure to pentachlorophenol.
MedLine Citation:
PMID:  12206139     Owner:  NLM     Status:  MEDLINE    
This study describes effects of exposure of the freshwater ciliate Tetrahymena pyriformis to the "classic" weak acid respiratory uncoupler pentachlorophenol (PCP) on the population growth kinetics and membrane lipid profiles. The assessment of growth kinetics of naive populations exposed to PCP, at concentrations eliciting < 50% growth inhibition, showed generation times of exposed cultures similar to generation times of controls but preceded by a short lag phase (< 2 h). Assessment of exposed cultures exhibiting > 50% growth inhibition revealed generation times that increased with increasing concentrations of toxicant. In addition, the relative percentages of selected fatty acid methyl esters (FAMEs) in both pellicle and mitochondrial membranes were examined. Upon exposure to PCP the relative percentages of FAMEs 12:0, 14:0, 16:0, 16:1, and 18:0 did not change. However, with exposure to PCP a decrease was observed for FAMEs 15:0 and 17:0. Conversely, with PCP exposure there was an increase in FAME 18:1. A comparison of these results with those elicited upon exposure to the model narcotic 1-octanol reveals marked differences in both growth kinetics and fatty acid shifts.
T W Schultz; G D Sinks; A P Bearden-Lowit
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell biology and toxicology     Volume:  18     ISSN:  0742-2091     ISO Abbreviation:  Cell Biol. Toxicol.     Publication Date:  2002  
Date Detail:
Created Date:  2002-09-02     Completed Date:  2003-03-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8506639     Medline TA:  Cell Biol Toxicol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  271-8     Citation Subset:  IM    
The University of Tennessee, College of Veterinary Medicine, Knoxville 37996-4543, USA.
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MeSH Terms
1-Octanol / pharmacology
Cell Division / drug effects
Cell Membrane / drug effects*
Chromatography, Gas
Dimethyl Sulfoxide / toxicity
Dose-Response Relationship, Drug
Fatty Acids / metabolism
Free Radical Scavengers / pharmacology
Pentachlorophenol / pharmacology,  toxicity*
Tetrahymena pyriformis / metabolism*
Time Factors
Reg. No./Substance:
0/Fatty Acids; 0/Free Radical Scavengers; 111-87-5/1-Octanol; 67-68-5/Dimethyl Sulfoxide; 87-86-5/Pentachlorophenol

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