| Population genetics of apolipoproteins A-IV, E, and H, and the angiotensin converting enzyme (ACE): associations with lipids, and apolipoprotein levels in American Samoans. | |
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MedLine Citation:
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PMID: 15252864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Distributions of alleles at three apolipoprotein loci (APO E, APO H, and APO A-IV) and an insertion/deletion (I/D) polymorphism at the angiotensin converting enzyme (ACE) locus among 274 American Samoans are described here. Genotypes at each locus are examined for associations with quantitative lipid (total cholesterol (total-c), LDL-cholesterol (LDL-c), HDL-cholesterol (HDL-c), and triglycerides) and apolipoprotein (APO AI, APO AII, APO E, and APO B) levels. Genotype frequencies at all four loci are in Hardy-Weinberg equilibrium. The most common APO A-IV genotype (1-1) was observed in 252 American Samoans (97%). The three most common APO E genotypes were 3-3 (47%), 3-4 (30%), and 2-3 (12%). The most frequent APO H genotype was 2-2 (86%). The most common ACE genotype (I/I) was observed in 75% of sampled individuals, and 23% were I/D heterozygotes. APO E genotypic variation was associated with total-c, HDL-c, LDL-c, and all four quantitative apolipoproteins (AI, AII, E, and B). APO A-IV genotypes were associated significantly with total cholesterol, LDL-c, and APO-B levels. APO H showed little association with any quantitative lipid or apolipoprotein. ACE D/D homozygotes had higher AII levels. ACE showed a consistent association with APO AII levels, with either APO A-IV or APO E as a covariate. The interaction term between ACE and APO E was also significantly associated with total-c and APO E levels, and the ACE genotype showed a significant main effect on APO AI levels in multivariate analyses. |
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Authors:
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Douglas E Crews; Lori J Fitton; Bruce A Kottke; M Ilyas Kamboh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of physical anthropology Volume: 124 ISSN: 0002-9483 ISO Abbreviation: Am. J. Phys. Anthropol. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-07-14 Completed Date: 2004-08-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400654 Medline TA: Am J Phys Anthropol Country: United States |
Other Details:
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Languages: eng Pagination: 364-72 Citation Subset: IM |
Copyright Information:
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Copyright 2003 Wiley-Liss, Inc. |
Affiliation:
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Department of Anthropology, Ohio State University, Columbus, Ohio 43210-1316, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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American Samoa Apolipoproteins / blood, genetics* Apolipoproteins A / blood Apolipoproteins E / blood Asian Continental Ancestry Group / genetics* Cholesterol / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Female Genetics, Population Glycoproteins / blood Humans Lipids / blood* Male Peptidyl-Dipeptidase A / blood* Triglycerides / blood beta 2-Glycoprotein I |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins; 0/Apolipoproteins A; 0/Apolipoproteins E; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Glycoproteins; 0/Lipids; 0/Triglycerides; 0/apolipoprotein A-IV; 0/beta 2-Glycoprotein I; 57-88-5/Cholesterol; EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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