Document Detail

Population distribution profiles of the activities of blood alanine and aspartate aminotransferase in the normal F344 inbred rat by age and sex.
MedLine Citation:
PMID:  1921327     Owner:  NLM     Status:  MEDLINE    
Data on the blood enzyme activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were collected from control male and female F344 rats participating in toxicity studies at 17, 30, 56, 80 and 106 weeks of age. The data were skewed to the right with significant deviation from normality. Applying the Box-Cox transformation, it was concluded that approximately normal distributions could be obtained by using the reciprocal transformation. In general, the males showed a greater degree of heterogeneity for both enzymes. Enzyme activities at 17 weeks were lowest for both ALT and AST. There was a high correlation between the activities of blood ALT and AST, with some animals showing dramatic transient increases. Significant differences among studies with respect to the enzyme activities in rats of the same age were demonstrated.
T Waner; A Nyska; R Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory animals     Volume:  25     ISSN:  0023-6772     ISO Abbreviation:  Lab. Anim.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-11-12     Completed Date:  1991-11-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0112725     Medline TA:  Lab Anim     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  263-71     Citation Subset:  IM    
Life Science Research Israel, Ness Ziona.
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MeSH Terms
Alanine Transaminase / blood*,  physiology
Aspartate Aminotransferases / blood*,  physiology
Normal Distribution
Rats, Inbred F344
Reference Values
Sex Characteristics*
Reg. No./Substance:
EC Aminotransferases; EC Transaminase

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