Document Detail


Population code for tracking velocity based on cerebellar Purkinje cell simple spike firing in monkeys.
MedLine Citation:
PMID:  11099819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Velocity is an important determinant of the simple spike discharge of cerebellar Purkinje cells. In a previous study, Purkinje cells in the intermediate and lateral cerebellum recorded during manual tracking were found to be tuned to a combination of direction and speed, (i.e. preferred velocity). In this study a population analysis of this simple spike discharge was used to determine whether the velocity of tracking could be predicted. For the majority (30/32) of direction-speed combinations, the population response accurately specified the target velocity. A temporal analysis showed how the population response gradually converged to the required velocity 200 ms prior to the onset of tracking. Therefore, the simple spike discharge of a Purkinje cell ensemble contains sufficient information to reconstruct target velocity, providing support for the hypothesis that the cerebellum controls or signals movement velocity.
Authors:
J D Coltz; M T Johnson; T J Ebner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  296     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-02-02     Completed Date:  2001-02-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Affiliation:
Department of Neuroscience, University of Minnesota, Lions Research Building, Minneapolis, MN 55455, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arm
Cerebellum / physiology*
Cues
Haplorhini
Psychomotor Performance / physiology*
Purkinje Cells / physiology*
Pursuit, Smooth / physiology*
Reaction Time / physiology*
Regression Analysis
Grant Support
ID/Acronym/Agency:
5R01-NS-18118/NS/NINDS NIH HHS; F31-MH-1430/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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