Document Detail

Population based study of rates of multiple pregnancies in Denmark, 1980-94.
MedLine Citation:
PMID:  9080993     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study trends in multiple pregnancies not explained by changes in maternal age and parity patterns. DESIGN: Trends in population based figures for multiple pregnancies in Denmark studied from complete national records on parity history and vital status. POPULATION: 497,979 Danish women and 803,019 pregnancies, 1980-94. MAIN OUTCOME MEASURES: National rates of multiple pregnancies, infant mortality, and stillbirths controlled for maternal age and parity. Special emphasis on primiparous women > or = 30 years of age, who are most likely to undergo fertility treatment. RESULTS: The national incidence of multiple pregnancies increased 1.7-fold during 1980-94, the increase primarily in 1989-94 and almost exclusively in primiparous women aged > or = 30 years, for whom the adjusted population based twinning rate increased 2.7-fold and the triplet rate 9.1-fold. During 1989-94, the adjusted yearly increase in multiple pregnancies for these women was 19% (95% confidence interval 16% to 21%) and in dizygotic twin pregnancies 25% (21% to 28%). The proportion of multiple births among infant deaths in primiparous women > or = 30 years increased from 11.5% to 26.9% during the study period. The total infant mortality, however, did not increase for these women because of a simultaneous significant decrease in infant mortality among singletons. CONCLUSIONS: A relatively small group of women has drastically changed the overall national rates of multiple pregnancies. The introduction of new treatments to enhance fertility has probably caused these changes and has also affected the otherwise decreasing trend in infant mortality. Consequently, the resources, both economical and otherwise, associated with these treatments go well beyond those invested in specific fertility enhancing treatments.
T Westergaard; J Wohlfahrt; P Aaby; M Melbye
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  314     ISSN:  0959-8138     ISO Abbreviation:  BMJ     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-30     Completed Date:  1997-04-30     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  775-9     Citation Subset:  AIM; E; IM    
Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Artillerivej, Copenhagen S, Denmark.
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MeSH Terms
Denmark / epidemiology
Fetal Death
Infant Mortality
Infant, Newborn
Maternal Age
Pregnancy, Multiple / statistics & numerical data*
Pregnant Women
Social Change*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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