| Population analysis of ethnicity and first-phase insulin release. | |
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MedLine Citation:
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PMID: 20570007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: A mechanistic, physiologically-based pharmacokinetic (PK/PD) model was developed to describe the biphasic insulin release and evaluate the racial effects on the glucose-insulin kinetics in response to intravenous glucose. METHODS: Fifteen African-American and 18 Caucasian children and adolescents between 8 and 18 years of age were enrolled in the study. Intravenous bolus of glucose (250 mg/kg) was administered and blood samples collected at frequent intervals for three hours following the glucose injection. A nonlinear mixed-effect population kinetic analysis with covariate structure was performed using Monolix. RESULTS: A significantly higher initial insulin secretion from a readily releasable pool, which is responsible for the first-phase insulin secretion, was detected in African-Americans compared to Caucasians (p<0.05). CONCLUSIONS: The proposed kinetic model is able to describe the glucose-stimulated insulin response, account for the first-phase insulin release and identify a racially-based pharmacokinetic difference in insulin's biphasic secretion behavior. It is hypothesized that the first-phase insulin component may play an important role in the development of type 2 diabetes. The proposed mechanistic model provides a quantitative analysis of the biphasic insulin release that may be useful in the early detection of diabetes. |
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Authors:
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Lanyi Xie; Robert P Hoffman; Peter Veng-Pedersen |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2010-05-31 |
Journal Detail:
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Title: Diabetes research and clinical practice Volume: 89 ISSN: 1872-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-10 Completed Date: 2010-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
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Languages: eng Pagination: 243-9 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent African Americans Child European Continental Ancestry Group Female Glucose / administration & dosage, pharmacokinetics* Humans Insulin / blood*, secretion* Male |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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