Document Detail

Population strategies to decrease sodium intake and the burden of cardiovascular disease: a cost-effectiveness analysis.
MedLine Citation:
PMID:  20194225     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Sodium consumption raises blood pressure, increasing the risk for heart attack and stroke. Several countries, including the United States, are considering strategies to decrease population sodium intake.
OBJECTIVE: To assess the cost-effectiveness of 2 population strategies to reduce sodium intake: government collaboration with food manufacturers to voluntarily cut sodium in processed foods, modeled on the United Kingdom experience, and a sodium tax.
DESIGN: A Markov model was constructed with 4 health states: well, acute myocardial infarction (MI), acute stroke, and history of MI or stroke.
DATA SOURCES: Medical Panel Expenditure Survey (2006), Framingham Heart Study (1980 to 2003), Dietary Approaches to Stop Hypertension trial, and other published data.
TARGET POPULATION: U.S. adults aged 40 to 85 years.
OUTCOME MEASURES: Incremental costs (2008 U.S. dollars), quality-adjusted life-years (QALYs), and MIs and strokes averted.
RESULTS OF BASE-CASE ANALYSIS: Collaboration with industry that decreases mean population sodium intake by 9.5% averts 513 885 strokes and 480 358 MIs over the lifetime of adults aged 40 to 85 years who are alive today compared with the status quo, increasing QALYs by 2.1 million and saving $32.1 billion in medical costs. A tax on sodium that decreases population sodium intake by 6% increases QALYs by 1.3 million and saves $22.4 billion over the same period.
RESULTS OF SENSITIVITY ANALYSIS: Results are sensitive to the assumption that consumers have no disutility with modest reductions in sodium intake.
LIMITATION: Efforts to reduce population sodium intake could result in other dietary changes that are difficult to predict.
CONCLUSION: Strategies to reduce sodium intake on a population level in the United States are likely to substantially reduce stroke and MI incidence, which would save billions of dollars in medical expenses.
PRIMARY FUNDING SOURCE: Department of Veterans Affairs, Stanford University, and National Science Foundation.
Crystal M Smith-Spangler; Jessie L Juusola; Eva A Enns; Douglas K Owens; Alan M Garber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-03-01
Journal Detail:
Title:  Annals of internal medicine     Volume:  152     ISSN:  1539-3704     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-05-31     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  481-7, W170-3     Citation Subset:  AIM; IM    
Veterans Affairs Palo Alto Healthcare System, Palo Alto, California, USA.
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MeSH Terms
Aged, 80 and over
Blood Pressure / physiology
Computer Simulation
Cost-Benefit Analysis
Diet, Sodium-Restricted
Fast Foods / economics*
Markov Chains
Middle Aged
Models, Cardiovascular
Myocardial Infarction / epidemiology,  physiopathology,  prevention & control*
Nutrition Policy*
Quality-Adjusted Life Years
Risk Factors
Sodium, Dietary / administration & dosage,  economics*
Stroke / epidemiology,  prevention & control*
United States
Reg. No./Substance:
0/Sodium, Dietary
Comment In:
Ann Intern Med. 2010 Aug 17;153(4):276; author reply 277   [PMID:  20713803 ]
Ann Intern Med. 2010 Apr 20;152(8):I27   [PMID:  20194227 ]
Ann Intern Med. 2010 Apr 20;152(8):526-7, W182   [PMID:  20194226 ]
Ann Intern Med. 2010 Aug 17;153(4):276; author reply 277   [PMID:  20713804 ]

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