| Population pharmacokinetics and pharmacodynamics of cisplatinum during hyperthermic intraperitoneal chemotherapy using a closed abdominal procedure. | |
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MedLine Citation:
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PMID: 20173087 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The aim of this work was to study the pharmacokinetics of cisplatinum during closed abdominal hyperthermic intraperitoneal chemotherapy (HIPEC) using a population pharmacokinetics approach. Forty patients were treated between January 2003 and December 2004. Peritoneal and blood concentrations of cisplatinum were used to develop a pharmacokinetic model of the peritoneal and plasma compartments using NONMEM software. Different covariables were analyzed to identify those that explain part of the interindividual variability of the pharmacokinetic parameters. Relationships between the area under the concentration-time curve (AUC) and hematological and renal toxicity and efficiency were explored. The pharmacokinetics of cisplatinum were modeled with a 3-compartment model. Estimations of the plasma and peritoneal pharmacokinetic parameters were obtained. No clinical or biological covariates correlated with these parameters. No direct relationship between the AUC of the peritoneal or plasma and toxicity or efficiency was demonstrated. The pharmacokinetics during HIPEC could be modeled with a 3-compartment model using a population pharmacokinetics approach. This work is the basis of further studies. Notably, studies including new patients will analyze the impact of abdominal cavity volume and the variation of the abdominal pressure during HIPEC on the pharmacokinetics of cisplatinum. |
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Authors:
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Eddy Cotte; Olivier Colomban; Jérome Guitton; Brigitte Tranchand; Nawel Bakrin; François-Noël Gilly; Olivier Glehen; Michel Tod |
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Publication Detail:
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Type: Journal Article Date: 2010-02-19 |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 51 ISSN: 1552-4604 ISO Abbreviation: J Clin Pharmacol Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 9-18 Citation Subset: IM |
Affiliation:
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Department of Digestive Surgery, Centre Hospitalo-Universitaire Lyon Sud, Pierre Bénite cedex, France. eddy.cotte@chu-lyon.fr |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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