Document Detail


Population pharmacokinetics of pentobarbital in neonates, infants, and children after open heart surgery.
MedLine Citation:
PMID:  21665222     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To determine the pharmacokinetics of pentobarbital in neonates, infants, and young children with congenital heart disease after open-heart surgery.
STUDY DESIGN: Thirty-five subjects (3.0 days-4.4 years) after open-heart surgery who received pentobarbital as standard of care were enrolled. Serial pharmacokinetic blood samples were obtained. A population-based, nonlinear mixed-effects modeling approach was used to characterize pentobarbital pharmacokinetics.
RESULTS: A two-compartment model with weight as a co-variate allometrically expressed on clearance (CL), inter-compartmental clearance, central (V1) and peripheral volume of distributions, bypass grafting time as a co-variate on CL and V1, and age and ventricular physiology as co-variates on CL best described the pharmacokinetics. A typical infant (two-ventricle physiology, 6.9 kg, 5.2 months, and bypass grafting time of 60 minutes) had a CL of 0.12 L/hr/kg, V1 of 0.45 L/kg, and peripheral volume of distributions of 0.98 L/kg. The bypass grafting effect was poorly estimated. For subjects <12 months age, an age effect on CL remained after accounting for weight and was precisely estimated.
CONCLUSIONS: Pentobarbital pharmacokinetics is influenced by age and weight. Subjects with single-ventricle physiology demonstrated a 15% decrease in clearance when compared with subjects with two-ventricle physiology.
Authors:
Athena F Zuppa; Susan C Nicolson; Jeffrey S Barrett; Marc R Gastonguay
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-06-12
Journal Detail:
Title:  The Journal of pediatrics     Volume:  159     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-17     Completed Date:  2011-11-08     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  414-419.e1-3     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Age Factors
Body Weight
Child, Preschool
Heart Defects, Congenital / surgery*
Humans
Hypnotics and Sedatives / blood,  pharmacokinetics*
Infant
Infant, Newborn
Pentobarbital / blood,  pharmacokinetics*
Time Factors
Grant Support
ID/Acronym/Agency:
K23 HD048817/HD/NICHD NIH HHS; K23 HD048817/HD/NICHD NIH HHS; K23 HD048817-04/HD/NICHD NIH HHS; K23 HD048817-05/HD/NICHD NIH HHS; UL1 RR024134/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Hypnotics and Sedatives; I4744080IR/Pentobarbital
Comments/Corrections
Comment In:
J Pediatr. 2011 Sep;159(3):361-3   [PMID:  21764403 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Controlled self-assembly of hydrophobic quantum dots through silanization.
Next Document:  The Effect of Calcium Supplementation on Blood Lead Levels in Nigerian Children.