| Population pharmacokinetic modeling of pantoprazole in pediatric patients from birth to 16 years. | |
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MedLine Citation:
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PMID: 20484619 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The population pharmacokinetics of pantoprazole was characterized in pediatric patients from birth to 16 years using NONMEM and evaluated via bootstrap and predictive check. Data were described using a 2-compartment model with a typical parameterized in terms of clearance (CL) (95% CI) of 1.93 L per hour (1.53, 2.61), given the reference covariates (female, full term, extensive/unknown CYP2C19 metabolizer status, non-African American, 10 kg weight, intravenous or tablet administration). Pantoprazole pharmacokinetic parameters appear to be similar in pediatric patients compared to adults when allometrically scaled. The effect of age on allometrically scaled CL was best described by a sigmoid Emax model with the age effect reaching an asymptote approximately equal to the adult CL by 1 year. CYP2C19 poor metabolizers exhibited reduced CL with the point estimate and 95% CI more than 70% lower than the typical value. Simulations from the final model indicated that the 1.2-mg/kg dose provides the best comparison to adults. |
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Authors:
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W Knebel; B Tammara; C Udata; G Comer; M R Gastonguay; X Meng |
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Publication Detail:
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Type: Journal Article Date: 2010-05-19 |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 51 ISSN: 1552-4604 ISO Abbreviation: J Clin Pharmacol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 333-45 Citation Subset: IM |
Affiliation:
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2 Tunxis Road, Suite 112, Tariffville, CT 06081; e-mail: billk@metrumrg.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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