Document Detail


PopED: An extended, parallelized, nonlinear mixed effects models optimal design tool.
MedLine Citation:
PMID:  22640817     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Several developments have facilitated the practical application and increased the general use of optimal design for nonlinear mixed effects models. These developments include new methodology for utilizing advanced pharmacometric models, faster optimization algorithms and user friendly software tools. In this paper we present the extension of the optimal design software PopED, which incorporates many of these recent advances into an easily useable enhanced GUI. Furthermore, we present new solutions to problems related to the design of experiments such as: faster and more robust FIM calculations and optimizations, optimizing over cost/utility functions and diagnostic tools and plots to evaluate design performance. Examples for; (i) Group size optimization and efficiency translation, (ii) Cost/constraint optimization, (iii) Optimizations with different FIM approximations and (iv) optimization with parallel computing demonstrate the new features in PopED and underline the potential use of this tool when designing experiments.
Authors:
Joakim Nyberg; Sebastian Ueckert; Eric A Strömberg; Stefanie Hennig; Mats O Karlsson; Andrew C Hooker
Related Documents :
21334727 - Modeling bioaccumulation in humans using poly-parameter linear free energy relationship...
25466147 - Application of rapid visco analyser (rva) viscograms and chemometrics for maize hardnes...
23304307 - Anomaly detection in clinical processes.
21269747 - Application of air pollution dispersion modeling for source-contribution assessment and...
21048947 - How wealth accumulation can promote cooperation.
21222347 - Energy availability from livestock and agricultural productivity in europe, 1815–1913: ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-26
Journal Detail:
Title:  Computer methods and programs in biomedicine     Volume:  -     ISSN:  1872-7565     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506513     Medline TA:  Comput Methods Programs Biomed     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
The Pharmacometrics Research Group, Department of Pharmaceutical Biosciences, Faculty of Pharmacy, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Semantic patient information aggregation and medicinal decision support.
Next Document:  Medical faculties educational network: Multidimensional quality assessment.