| Poorly differentiated thyroid carcinoma: 5 years after the 2004 WHO classification of endocrine tumours. | |
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MedLine Citation:
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PMID: 19960273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poorly differentiated thyroid carcinoma (PDTC) was originally described in 1983 but included in the WHO classification of thyroid tumours in the 2004 edition, only. The diagnostic problems encountered in the 5 years of application of the WHO criteria are reviewed here. A long debate is still going on about the nature of PDTC, its morphological diagnostic features, its clinical significance and its optimal therapeutic approach. A consensus conference held in Turin in 2006 confirmed the geographical differences among claimed classical forms of PDTC and suggested a diagnostic algorithm based on the presence of a solid/trabecular/insular growth pattern and of high-grade features, in line with the WHO definition of PDTC, capable to select tumours with a distinct aggressive clinical behaviour. This worked well for PDTC cases from mountain areas (e.g. Northern Italy), where most, if not all, thyroid carcinomas having high-grade features also share a solid/trabecular/insular pattern of growth. However, this scheme might be less easily applicable for American and Japanese cases, possibly due to heterogeneous architectural and cytological features; indeed some Authors still prefer to base their diagnostic work up on the recognition of high-grade features only, including mitotic index and necrosis, irrespective of the growth pattern. |
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Authors:
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Marco Volante; Mauro Papotti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Endocrine pathology Volume: 21 ISSN: 1559-0097 ISO Abbreviation: Endocr. Pathol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-09 Completed Date: 2010-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9009288 Medline TA: Endocr Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 1-6 Citation Subset: IM |
Affiliation:
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Department of Clinical and Biological Sciences at San Luigi Hospital, University of Turin, Regione Gonzole 10, 10043, Orbassano, Turin, Italy. marco.volante@unito.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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classification,
diagnosis,
pathology*,
ultrastructure Humans Thyroid Neoplasms / classification, diagnosis, pathology*, ultrastructure World Health Organization |
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