| Poor verbal working memory across intellectual level in boys with Duchenne dystrophy. | |
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MedLine Citation:
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PMID: 10851376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether all boys with Duchenne muscular dystrophy (DMD) have a similar verbal and memory profile of skills, or whether only a subset is affected, and to determine whether the weak areas in their profile are substantially different from a control group. METHODS: Performance of patients with DMD on neuropsychological tests of verbal and memory skills was examined in two ways. Standardized test scores for 80 boys with DMD (estimated IQ range, 70 to 160) were ranked individually from worst to best, and the individual rankings were compared across the group using Friedman rank analysis. Additionally, performance of 41 boys with DMD was compared with that of their sibling control subjects of similar age and estimated IQ using multivariate analysis of variance. RESULTS: Individual cognitive profiles were significantly similar among the subjects with DMD, such that for most subjects digit span, story recall, and comprehension were the tests on which each performed most poorly. This finding remained true regardless of whether they were of high or low intellectual function. In contrast, no significant cognitive profile was found among their sibling control subjects, and when compared with their siblings, the DMD group scored significantly more poorly on digit span, comprehension, and story recall, but not on other verbal and memory measures. CONCLUSIONS: Boys with DMD have a specific cognitive profile, regardless of their general level of cognitive function. Specifically, boys with DMD performed more poorly on tests requiring attention to complex verbal information than they did on other verbal or memory measures. The possibility that the missing dystrophin brain products may contribute to selective cognitive processing is considered. |
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Authors:
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V J Hinton; D C De Vivo; N E Nereo; E Goldstein; Y Stern |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurology Volume: 54 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-07-13 Completed Date: 2000-07-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2127-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, the College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Analysis of Variance Child Cognition* Humans Intelligence* Intelligence Tests / statistics & numerical data Male Memory* Muscular Dystrophy, Duchenne / epidemiology, physiopathology*, psychology Neuropsychological Tests Statistics, Nonparametric |
| Grant Support | |
ID/Acronym/Agency:
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R29 HD034155-04/HD/NICHD NIH HHS; R29 HD034155-05/HD/NICHD NIH HHS; R29 HD34155/HD/NICHD NIH HHS |
| Comments/Corrections | |
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