Document Detail


Poor verbal working memory across intellectual level in boys with Duchenne dystrophy.
MedLine Citation:
PMID:  10851376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether all boys with Duchenne muscular dystrophy (DMD) have a similar verbal and memory profile of skills, or whether only a subset is affected, and to determine whether the weak areas in their profile are substantially different from a control group.
METHODS: Performance of patients with DMD on neuropsychological tests of verbal and memory skills was examined in two ways. Standardized test scores for 80 boys with DMD (estimated IQ range, 70 to 160) were ranked individually from worst to best, and the individual rankings were compared across the group using Friedman rank analysis. Additionally, performance of 41 boys with DMD was compared with that of their sibling control subjects of similar age and estimated IQ using multivariate analysis of variance.
RESULTS: Individual cognitive profiles were significantly similar among the subjects with DMD, such that for most subjects digit span, story recall, and comprehension were the tests on which each performed most poorly. This finding remained true regardless of whether they were of high or low intellectual function. In contrast, no significant cognitive profile was found among their sibling control subjects, and when compared with their siblings, the DMD group scored significantly more poorly on digit span, comprehension, and story recall, but not on other verbal and memory measures.
CONCLUSIONS: Boys with DMD have a specific cognitive profile, regardless of their general level of cognitive function. Specifically, boys with DMD performed more poorly on tests requiring attention to complex verbal information than they did on other verbal or memory measures. The possibility that the missing dystrophin brain products may contribute to selective cognitive processing is considered.
Authors:
V J Hinton; D C De Vivo; N E Nereo; E Goldstein; Y Stern
Related Documents :
8743306 - Cognitive rehabilitation following anterior communicating artery aneurysm bleeding: a c...
19952876 - Verbal working memory impairment in patients with current episode of unipolar major dep...
22752816 - Great apes infer others' goals based on context.
2479436 - Visual imagery as a cognitive means of compensation for brain injury.
2326136 - Restricting the field of view: perceptual and performance effects.
9599136 - Dissociating the wheat from the chaff in theories of hypnosis: reply to kihlstrom (1998...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  54     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-13     Completed Date:  2000-07-13     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2127-32     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, the College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Analysis of Variance
Child
Cognition*
Humans
Intelligence*
Intelligence Tests / statistics & numerical data
Male
Memory*
Muscular Dystrophy, Duchenne / epidemiology,  physiopathology*,  psychology
Neuropsychological Tests
Statistics, Nonparametric
Grant Support
ID/Acronym/Agency:
R29 HD034155-04/HD/NICHD NIH HHS; R29 HD034155-05/HD/NICHD NIH HHS; R29 HD34155/HD/NICHD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Antiretroviral therapy may improve sensory function in HIV-infected patients: a pilot study.
Next Document:  A three-sister sibship of Gerstmann-Sträussler-Scheinker disease with a CJD phenotype.