| Poor prognosis for ovarian response to stimulation: results of a randomised trial comparing the flare-up GnRH agonist protocol vs. the antagonist protocol. | |
| | |
MedLine Citation:
|
PMID: 20196635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine the efficacy of the flare-up agonist and the antagonist protocols in patients with poor prognosis for ovarian response. METHODS: A randomised trial was conducted on two hundred and twenty-one women considered as having poor prognosis for ovarian response to stimulation, based on previous cycles or clinical criteria. All women were prospectively randomised into two groups of treatment (flare-up group and antagonist group) by computer-assisted randomisation in a 1:1 ratio. The main outcome measure was clinical pregnancy rate. RESULTS: Groups were homogeneous in age and baseline characteristics. Duration of stimulation, gonadotropin consumption, number of oocytes retrieved and number and quality of embryos transferred did not differ significantly between the groups. E(2) level the day of hCG administration was significantly higher in the flare-up group. Pregnancy rates per started cycle were 15% in the flare-up group and 14.1% in the antagonist group. Cancellation rates were 12.5% in the flare-up group and 16.3% in the antagonist group. None of these differences reached statistical significance. CONCLUSIONS: No statistically significant differences were observed between the two protocols regarding clinical pregnancy rates. In patients with poor prognosis for ovarian response, the flare-up agonist and the antagonist protocols were comparable regarding clinical pregnancy rates. |
| | |
Authors:
|
Marta Devesa; Francisca Martínez; Buenaventura Coroleu; Rosa Tur; Clara González; Ignacio Rodríguez; Pedro N Barri |
Related Documents
:
|
11239535 - Role of periovulatory luteinizing hormone concentrations during assisted reproductive t... 7890055 - A comparative prospective study of conventional regimen with chronic low-dose administr... 18616885 - Ovulation induction with tamoxifen and alternate-day gonadotrophin in patients with thi... 8419205 - No detrimental effects in delaying initiation of gonadotropin administration after pitu... 17375625 - The effect of pre-pregnancy weight on delivery outcome and birth weight in potential di... 7805985 - Primary twin ovarian pregnancy. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 26 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-06-14 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
|
Languages: eng Pagination: 509-15 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynaecology, Institut Universitari Dexeus, Barcelona, Spain. mardev@dexeus.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Analysis of Variance Embryo Transfer Female Follicle Stimulating Hormone, beta Subunit / therapeutic use* Gonadotropin-Releasing Hormone / analogs & derivatives*, therapeutic use Hormone Antagonists / therapeutic use Humans Infertility, Female / therapy* Ovulation Induction / methods* Patient Selection Pregnancy Pregnancy Rate Prospective Studies Recombinant Proteins / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Follicle Stimulating Hormone, beta Subunit; 0/Hormone Antagonists; 0/Recombinant Proteins; 123246-29-7/ganirelix; 33515-09-2/Gonadotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Low-dose vaginal estrogens or vaginal moisturizer in breast cancer survivors with urogenital atrophy...
Next Document: Placental weight, digitally derived placental dimensions at term and their relationship to birth wei...