Document Detail

Poor postnatal weight gain: a risk factor for severe retinopathy of prematurity.
MedLine Citation:
PMID:  11124668     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This study aimed to investigate the relationship between rate of postnatal weight gain and severity of retinopathy of prematurity (ROP). METHODS: All infants (n = 111) screened for ROP at a single tertiary intensive care nursery over a 2-year period with an estimated gestational age of 30 weeks or less and follow-up to at least 42 weeks' postconception were included. The authors performed a retrospective review of records and statistical analysis of risk factors for ROP using multivariate analysis. RESULTS: Infants with severe (stage 3 or greater) ROP gained an average 10.9 g/kg per day in the first 6 weeks of life, compared to a mean of 9.6 g/kg per day for those with mild or no ROP (P =.04). By multiple regression, which included birth weight, gestational age, and 9 other reported risk factors, there was an association between rate of postnatal weight gain and severity of ROP (P =.02). By stepwise regression, 4 variables were associated with ROP severity: estimated gestational age at birth (P =.002), rate of postnatal weight gain (P = .0002), volume of transfused erythrocytes (P =.0001), and culture-proven sepsis (P = .02). CONCLUSION: Poor postnatal weight gain is a risk factor for the development of severe (stage 3 or greater) ROP. Ophthalmologists should take note of those infants who gain less than 50% of their birth weight in the first 6 weeks of life.
D K Wallace; J A Kylstra; S J Phillips; J G Hall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus     Volume:  4     ISSN:  1091-8531     ISO Abbreviation:  J AAPOS     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-10     Completed Date:  2001-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9710011     Medline TA:  J AAPOS     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  343-7     Citation Subset:  IM    
Departments of Ophthalmology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7040, USA.
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MeSH Terms
Disease Progression
Gestational Age
Infant, Low Birth Weight
Infant, Newborn
Retinopathy of Prematurity / diagnosis,  etiology*
Retrospective Studies
Risk Factors
Severity of Illness Index
Weight Gain*
Comment In:
J AAPOS. 2001 Jun;5(3):198   [PMID:  11404749 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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