| Poor ovarian response in patients younger than 35 years: is it also a qualitative decline in ovarian function? | |
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MedLine Citation:
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PMID: 19544121 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate whether poor response to controlled ovarian stimulation (COS) is due to a qualitative decline in ovarian function. METHODS: This retrospective cohort study included 436 patients younger than 35-years old, undergoing COS for intracytoplasmic sperm injection (ICSI). Patients with four or fewer MII oocytes after COS (poor-responder group, PR, n = 52) were age-matched with normoresponder patients (NR, n = 364). RESULTS: Although similar duration of stimulation (10.5 +/- 0.4 and 9.3 +/- 0.8 days; p = 0.1358), increased doses of gonadotrophins (2510 +/- 865 and 2253 +/- 572 IU; p = 0.0061) were used in the PR. The results show a increased chance of cycle ending of PR (PR: 26.9% and NR: 3.1%; p < 0.0001). Although the lower total number of oocytes retrieved (2.4 +/- 1.4 and 16.2 +/- 9.3; p < 0.0001), equal rate of fertilization (70.2% and 72.0%, p = 0.1190) and high quality embryos were obtained (50.0% and 45.2%; p = 0.4895), resulting in similar implantation (14.5% and 19.7%; p = 0.2246) and abortion (10.0% and 15.4%; p = 1.00) rates, respectively. A trend towards increased pregnancy rate per embryo transfer in NR group was noted (PR: 26.3% and NR: 42.2%; p = 0.0818). CONCLUSIONS: Low ovarian response could be associated mainly with a quantitative rather than a qualitative decline in ovarian function. Therefore, even if the ovarian response to stimulation is low, patients aged < or =35 years should process to oocyte retrieval. |
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Authors:
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Rita De C??ssia S??vio Figueira; Daniela Paes Almeida Ferreira Braga; Marc??lio Nichi; Camila Madaschi; Luciana Semi??o-Francisco; Assumpto Iaconelli; Edson Borges |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Human fertility (Cambridge, England) Volume: 12 ISSN: 1742-8149 ISO Abbreviation: Hum Fertil (Camb) Publication Date: 2009 |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888143 Medline TA: Hum Fertil (Camb) Country: England |
Other Details:
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Languages: eng Pagination: 160-5 Citation Subset: IM |
Affiliation:
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Fertility-Assisted Fertilization Center, S??o Paulo, SP, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aging / physiology Chi-Square Distribution Chorionic Gonadotropin / administration & dosage*, blood Embryo Implantation / physiology* Embryo Transfer Estradiol / blood Female Humans Oocyte Retrieval Oocytes / physiology* Ovary / physiology* Ovulation Induction* Pregnancy Pregnancy Rate Retrospective Studies Sperm Injections, Intracytoplasmic / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 50-28-2/Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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