Document Detail

Poor ovarian response in patients younger than 35 years: is it also a qualitative decline in ovarian function?
MedLine Citation:
PMID:  19544121     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate whether poor response to controlled ovarian stimulation (COS) is due to a qualitative decline in ovarian function. METHODS: This retrospective cohort study included 436 patients younger than 35-years old, undergoing COS for intracytoplasmic sperm injection (ICSI). Patients with four or fewer MII oocytes after COS (poor-responder group, PR, n = 52) were age-matched with normoresponder patients (NR, n = 364). RESULTS: Although similar duration of stimulation (10.5 +/- 0.4 and 9.3 +/- 0.8 days; p = 0.1358), increased doses of gonadotrophins (2510 +/- 865 and 2253 +/- 572 IU; p = 0.0061) were used in the PR. The results show a increased chance of cycle ending of PR (PR: 26.9% and NR: 3.1%; p < 0.0001). Although the lower total number of oocytes retrieved (2.4 +/- 1.4 and 16.2 +/- 9.3; p < 0.0001), equal rate of fertilization (70.2% and 72.0%, p = 0.1190) and high quality embryos were obtained (50.0% and 45.2%; p = 0.4895), resulting in similar implantation (14.5% and 19.7%; p = 0.2246) and abortion (10.0% and 15.4%; p = 1.00) rates, respectively. A trend towards increased pregnancy rate per embryo transfer in NR group was noted (PR: 26.3% and NR: 42.2%; p = 0.0818). CONCLUSIONS: Low ovarian response could be associated mainly with a quantitative rather than a qualitative decline in ovarian function. Therefore, even if the ovarian response to stimulation is low, patients aged < or =35 years should process to oocyte retrieval.
Rita De C??ssia S??vio Figueira; Daniela Paes Almeida Ferreira Braga; Marc??lio Nichi; Camila Madaschi; Luciana Semi??o-Francisco; Assumpto Iaconelli; Edson Borges
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human fertility (Cambridge, England)     Volume:  12     ISSN:  1742-8149     ISO Abbreviation:  Hum Fertil (Camb)     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888143     Medline TA:  Hum Fertil (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  160-5     Citation Subset:  IM    
Fertility-Assisted Fertilization Center, S??o Paulo, SP, Brazil.
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MeSH Terms
Aging / physiology
Chi-Square Distribution
Chorionic Gonadotropin / administration & dosage*,  blood
Embryo Implantation / physiology*
Embryo Transfer
Estradiol / blood
Oocyte Retrieval
Oocytes / physiology*
Ovary / physiology*
Ovulation Induction*
Pregnancy Rate
Retrospective Studies
Sperm Injections, Intracytoplasmic / drug effects*
Reg. No./Substance:
0/Chorionic Gonadotropin; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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