Document Detail


Poor outcome in end-stage heart failure patients with low circulating calcitriol levels.
MedLine Citation:
PMID:  18304873     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Vitamin D receptor knockout mice develop typical signs of congestive heart failure (CHF). In approximately 20% of stable CHF patients, frankly low concentrations of the vitamin D hormone calcitriol are found.
AIMS: We investigated whether serum calcitriol concentrations predict clinical outcome in end-stage CHF.
METHODS AND RESULTS: We collected blood samples in 383 end-stage CHF patients who were on a waiting list for cardiac transplantation. We assessed associations of calcitriol with disease severity and freedom from event (death or cardiac transplantation) during 1-year follow-up. In electively listed patients (n=325), 31% had deficient calcitriol levels (<43 pmol/l) compared to 47% in urgently/high urgently listed patients (n=58; P<0.001). As determined by multivariable logistic regression, calcitriol was an independent predictor of the listing status 'urgent/high urgent' (P<0.001). Calcitriol concentrations were also significantly lower in patients with an event (n=233) compared to those who survived on the waiting list (P<0.001). Cox regression analysis revealed that patients in the highest calcitriol tertile had a hazard ratio (95% CI) for an event of 0.506 (0.334-0.767) compared with patients in the lowest calcitriol tertile (P=0.005), after adjustment for potential confounders.
CONCLUSION: Data indicate that low serum calcitriol concentrations are independently associated with poor clinical outcome in end-stage CHF.
Authors:
Armin Zittermann; Stefanie S Schleithoff; Christian Götting; Oxana Dronow; Uwe Fuchs; Joachim Kuhn; Knut Kleesiek; Gero Tenderich; Reiner Koerfer
Related Documents :
21085833 - Recurrent pulmonary hyalinizing granuloma.
2160883 - Clinical experience with lisinopril in congestive heart failure. focus on the older pat...
22004233 - Shrinking lung syndrome in systemic lupus erythematosus patients; clinical characterist...
Publication Detail:
Type:  Journal Article     Date:  2008-03-04
Journal Detail:
Title:  European journal of heart failure     Volume:  10     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-11     Completed Date:  2008-08-26     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  321-7     Citation Subset:  IM    
Affiliation:
Klinik für Thorax- und Kardiovaskularchirurgie, Herz- und Diabeteszentrum NRW, Ruhr Universität Bochum, Georgstrasse 11, D-32545 Bad Oeynhausen, Germany. azittermann@hdz-nrw.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Calcitriol / blood*
Cross-Sectional Studies
Female
Heart Failure / blood*,  mortality*
Humans
Kaplan-Meier Estimate
Logistic Models
Male
Middle Aged
Prognosis
Prospective Studies
Severity of Illness Index
Chemical
Reg. No./Substance:
32222-06-3/Calcitriol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prognostic impact of NT-proBNP and renal function in comparison to contemporary multi-marker risk sc...
Next Document:  Hemophilic joint disease - current perspective and potential future strategies.