| Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen. | |
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MedLine Citation:
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PMID: 19616411 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We have previously demonstrated that putaminal but not caudate volumes are associated with poor outcome in patients with chronic schizophrenia. Present longitudinal study was designed to investigate progressive differences in striatal volumes among chronic schizophrenia patients with different outcomes and healthy subjects. METHODS: Structural MRI scans were acquired at baseline and at follow-up four years later to evaluate volumetric changes in 26 poor-outcome schizophrenia patients, 23 good-outcome patients and 16 healthy subjects. RESULTS: Schizophrenia patients with different outcomes entered the study with similar volumes of the caudate nucleus and putamen. The rate of decline in volumes of the putamen was greater in patients with poor outcome than in the good-outcome group, so that their putaminal but not caudate volumes were significantly smaller at the time of follow-up. There were no differences in baseline and follow-up volumes of the putamen or in the rate of their progression among patients with schizophrenia and healthy comparison subjects. The caudate volumes were lower in schizophrenia patients than healthy subjects at baseline and follow-up, but showed no differential patterns of progression between the groups. CONCLUSIONS: Volumes of the putamen may represent a longitudinal marker of treatment responsiveness and outcome in patients with chronic schizophrenia. |
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Authors:
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Serge A Mitelman; Emily L Canfield; King-Wai Chu; Adam M Brickman; Lina Shihabuddin; Erin A Hazlett; Monte S Buchsbaum |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-07-18 |
Journal Detail:
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Title: Schizophrenia research Volume: 113 ISSN: 1573-2509 ISO Abbreviation: Schizophr. Res. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-11 Completed Date: 2009-10-29 Revised Date: 2010-09-07 |
Medline Journal Info:
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Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 241-5 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA. serge.mitelman@mssm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Caudate Nucleus / pathology Chronic Disease Disease Progression Female Functional Laterality Humans Longitudinal Studies Magnetic Resonance Imaging / methods Male Middle Aged Psychiatric Status Rating Scales Putamen / pathology* Reference Values Schizophrenia / pathology* Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
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MH 077146/MH/NIMH NIH HHS; MH 56489/MH/NIMH NIH HHS; MH 60023/MH/NIMH NIH HHS; P50 MH66392-01/MH/NIMH NIH HHS; R03 MH077146-02/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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