| Poor neurological sequelae of herpes simplex virus encephalitis in an infant despite adequate antiviral and adjunct corticosteroid therapy. | |
| | |
MedLine Citation:
|
PMID: 22345788 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
A 2-month-old infant presented to our emergency department with fever, altered consciousness, and focal seizures of acute onset. He had vesicular skin lesions over the right preauricular region. CT brain showed a large hypodense lesion involving the left temporo-parietal region, left basal ganglia and left thalamus. MRI brain revealed bilateral multifocal corticomedullary lesions suggestive of encephalitis. CSF-PCR was positive for herpes simplex virus (HSV) type I. He was treated with standard dose intravenous acyclovir for 15 days along with a trial of pulse methylprednisolone, but was readmitted within a week with features of an early relapse. The infant survived but developed significant neurological sequelae. Although treatment of HSV is available, the neurological outcome is guarded even with adequate antiviral therapy. Adjunct corticosteroid therapy did not appear to attenuate the neurological sequelae. |
| | |
Authors:
|
Ratna B Basak; Varsha Malpani; Khalid Kakish; Susan Vargese; Nageshwar Chauhan; Andreas Boeck |
Related Documents
:
|
7424808 - Abnormalities of hair zinc concentration in mothers of newborn infants with spina bifida. 22368668 - Pulse oximetry screening for clinically unrecognized critical congenital heart disease ... 14713148 - Quinolizidine alkaloid profiles of two taxa of teline maderensis. 19824748 - Finding little albert: a journey to john b. watson's infant laboratory. 5365338 - Disseminated fibrin thromboembolism among neonates dying more than 48 hours after birth. 9764868 - Magnesium sulfate as an anticonvulsant in eclampsia. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Indian journal of dermatology Volume: 56 ISSN: 1998-3611 ISO Abbreviation: Indian J Dermatol Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2012-02-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370750 Medline TA: Indian J Dermatol Country: India |
Other Details:
|
Languages: eng Pagination: 749-51 Citation Subset: - |
Affiliation:
|
Department of Pediatrics, Alain Hospital-affiliate to Medical University of Vienna, Alain, United Arab Emirates . |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Idiopathic unilateral lower limb gangrene in a neonate.
Next Document: Disseminated granuloma annulare: a cutaneous adverse effect of anti-tnf agents.