Document Detail

Poor elemental food quality reduces the toxicity of fluoxetine on Daphnia magna.
MedLine Citation:
PMID:  18037510     Owner:  NLM     Status:  MEDLINE    
Most chemical contaminants released into the aquatic environment have been tested for their toxicity to aquatic organisms using standardized test protocols. The extent that results from such toxicity tests vary with the quality of food provided to the test organism remains largely unknown. Here, we determined whether the elemental food quality consumed by a common test organism, Daphnia magna, affects the toxicity of a pharmaceutical, fluoxetine. We found strong interactive effects of food quality and fluoxetine on daphnid survival, growth, and reproduction. Specifically, we found that D. magna fed phosphorus (P)- and nitrogen (N)-rich algal food experienced greater toxicity due to fluoxetine. For example, the 6-day LC(50) values for fluoxetine decreased from 0.33 to 0.15 mg L(-1) when food C:P ratios were increased from 100 to 800. One explanation for this result is that fluoxetine, as a selective serotonin reuptake inhibitor, increases the activity of serotonin, whose production is linked to growth metabolism in D. magna. A regulatory role of serotonin for D. magna's growth and reproduction would be consistent with its mitogenic roles in other organisms, although this possibility would require further study. Nevertheless, these results demonstrate the need to consider elemental food quality in ecotoxicological testing protocols that are aimed at evaluating the risks of exposure to chemicals in the aquatic environment.
Laura K Hansen; Paul C Frost; James H Larson; Chris D Metcalfe
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-23
Journal Detail:
Title:  Aquatic toxicology (Amsterdam, Netherlands)     Volume:  86     ISSN:  0166-445X     ISO Abbreviation:  Aquat. Toxicol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-21     Completed Date:  2008-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500246     Medline TA:  Aquat Toxicol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  99-103     Citation Subset:  IM    
Department of Biology, Trent University, Peterborough, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Algae / chemistry
Analysis of Variance
Animal Feed / standards*
Daphnia / drug effects*,  growth & development
Fluoxetine / analysis,  toxicity*
Food Analysis
Lethal Dose 50
Reproduction / drug effects
Serotonin Uptake Inhibitors / toxicity*
Survival Analysis
Time Factors
Water / analysis
Water Pollutants, Chemical / toxicity*
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 0/Water Pollutants, Chemical; 54910-89-3/Fluoxetine; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inhibition of red seabream iridovirus (RSIV) replication by small interfering RNA (siRNA) in a cell ...
Next Document:  Characteristics of clock drawing test (CDT) errors by the dementia type: quantitative and qualitativ...