Document Detail

Poor correlation between spectrophotometric intracutaneous analysis and histopathology in melanoma and nonmelanoma lesions.
MedLine Citation:
PMID:  23296145     Owner:  NLM     Status:  MEDLINE    
Spectrophotometric intracutaneous analysis (SIAscopy) is an imaging technique developed for diagnostics of pigmented skin lesions. By image analysis, the displayed images indicate the potential distribution and position of melanin, blood, and collagen within the lesion. A topographic comparison was performed between SIAscopic findings and histopathology. In total, 60 patients with suspicious pigmented skin lesions were included. The lesions were SIAscopically imaged and documented before excision and histopathological preparation. Topographical comparisons between SIAscopy findings and histopathology were made. A sensitivity and specificity of 24% and 84%, respectively, were obtained for invasive melanomas. The positive and negative predicted values were 58% and 54%, respectively. The features indicating dermal melanin, blood displacement and collagen holes did only show "no" to "slight" agreement with histopathology, i.e., κ ≤ 0.21. It was concluded that (i) SIAscopy-based diagnosis has low diagnostic accuracy for melanoma, (ii) single SIAscopic features do not provide reliable diagnostic information relating to the lesions internal structure on histopathology examination and (iii) SIAscopy cannot be used as a guide for localizing the maximum tumor thickness when performing the histopathological examination. The importance of validating new optical tools for tumor diagnostics with histopathological findings was demonstrated.
Karin Terstappen; Mart Suurküla; Håkan Hallberg; Marica B Ericson; Ann-Marie Wennberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  18     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-01-08     Completed Date:  2013-06-06     Revised Date:  2013-08-06    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  061223     Citation Subset:  IM    
University of Gothenburg, Department of Dermatology, 413 45 Gothenburg, SwedenbSkaraborg Hospital, Department of Dermatology, 541 85 Skövde, Sweden.
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MeSH Terms
Dermatology / methods
Image Interpretation, Computer-Assisted
Melanins / metabolism
Melanoma / diagnosis*,  metabolism,  pathology*
Neoplasm Invasiveness / diagnosis,  pathology
Optical Phenomena
Reproducibility of Results
Skin Diseases / diagnosis,  metabolism,  pathology
Skin Neoplasms / diagnosis*,  metabolism,  pathology*
Spectrophotometry / methods*
Reg. No./Substance:
Erratum In:
J Biomed Opt. 2013 Jun;18(6):069804

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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