Document Detail


Poor correlation between coronary artery calcification and obstructive coronary artery disease in an end-stage renal disease patient.
MedLine Citation:
PMID:  18271835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vascular calcification is highly prevalent and often severe in patients with chronic kidney disease. Arterial calcification in patients with chronic kidney disease can result from the deposition of mineral along the intimal layer of arteries in conjunction with atheromatous plaques or from calcium deposition in the medial wall of arteries, also known as Monckeberg's sclerosis. Whether coronary artery calcium scores as measured by electron beam computed tomography correlate with occlusive atherosclerotic disease in the dialysis population is uncertain. Here we report a case of an asymptomatic patient with diabetes mellitus and end-stage renal disease undergoing maintenance hemodialysis, who was found to have extremely elevated coronary artery calcium scores on electron beam computed tomography, but varied degrees of atherosclerotic plaque in her coronary arteries on coronary angiography. This suggests that in addition to the calcification anticipated in a remodeled intima, a proportion of the calcification is also likely to be in the arterial media. Thus, this case demonstrates that even an extremely high coronary calcium score may not be a satisfactory surrogate marker for obstructive atherosclerosis in elderly diabetic dialysis patients.
Authors:
Li-Li Tong; Rajnish Mehrotra; David M Shavelle; Matthew Budoff; Sharon Adler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Hemodialysis international. International Symposium on Home Hemodialysis     Volume:  12     ISSN:  1492-7535     ISO Abbreviation:  Hemodial Int     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-02-14     Completed Date:  2008-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101093910     Medline TA:  Hemodial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  16-22     Citation Subset:  IM    
Affiliation:
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor, UCLA Medical Center, Torrance, California, U.S.A.
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MeSH Terms
Descriptor/Qualifier:
Arterial Occlusive Diseases / epidemiology*
Cadaver
Calcinosis / epidemiology*
Coronary Disease / epidemiology*
Education, Medical, Continuing
Humans
Kidney Failure, Chronic / complications*,  therapy
Kidney Transplantation / statistics & numerical data
Living Donors / statistics & numerical data
Los Angeles
Nephrology / statistics & numerical data
Renal Dialysis / methods*
Schools, Medical
Tissue Donors / statistics & numerical data
Grant Support
ID/Acronym/Agency:
RR18298/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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