Document Detail

Poor baroreflex gain is a marker of heightened sympathetic activity post-tachycardia termination in humans.
MedLine Citation:
PMID:  14673695     Owner:  NLM     Status:  MEDLINE    
We hypothesized that sympathetic nerve activity (SNA) remains elevated after tachycardia termination in patients with low baroreflex gain (BRG), and decreased to or below baseline in patients with high BRG. In a cohort of patients who participated in a previously published study [3], BRG, SNA, blood pressure, and central venous pressure were measured immediately after the termination of simulated tachycardia. While the hemodynamic responses following tachycardia termination were similar in both groups, SNA remained elevated in patients with low BRG compared to a decrease below baseline levels in patients with high BRG (p = 0.04). Increased sympathetic activity following tachycardia termination could be arrhythmogenic and might play a role in the genesis of recurrent ventricular arrhythmias following tachycardia termination.
Robert C Kowal; Stephen L Wasmund; Michael L Smith; Richard L Page; Jose A Joglar; Mohamed H Hamdan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  13     ISSN:  0959-9851     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-15     Completed Date:  2004-08-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  443-6     Citation Subset:  IM    
Division of Cardiology, Dept. of Internal Medicine, University of Texas, Southwestern Medical Center, Room C57.102, 5323 Harry Hines Blvd, Dallas, TX 75390-9047, USA.
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MeSH Terms
Cardiac Pacing, Artificial*
Cohort Studies
Sympathetic Nervous System / physiopathology*
Tachycardia / physiopathology*,  therapy*

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