Document Detail


Poor Sleep and Cardiovascular Function in Children.
MedLine Citation:
PMID:  21555678     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We investigated whether sleep quantity and quality were related to 24-hour ambulatory blood pressure and cardiovascular reactivity in children. We studied term-born, healthy 8.0-year olds (SD: 1.4 years) without sleep-disordered breathing (231 and 265 children provided valid data for analyses of ambulatory blood pressure and cardiovascular reactivity, respectively). Sleep was registered with an actigraph for 6 nights on average (SD: 1.2; range: 3 to 13 nights). Ambulatory blood pressure was measured for 24-hours (41% nonschool days) with an oscillometric device. The children underwent the Trier Social Stress Test for Children, during which blood pressure, electrocardiography, and thoracic impedance were recorded and processed offline to give measures of cardiovascular and autonomic function. Neither quantity nor quality of sleep was related to 24-hour ambulatory blood pressure or cardiovascular reactivity after accounting for major covariates (sex, age, height, body mass index, and parental education). Although lower sympathetic nervous system activation and higher cardiac activation under stress were found in the group of children who slept for short duration when they were compared with the average sleep duration group, these associations were not significant after correction for multiple testing and were not seen in linear regression models of the effects of sleep duration. These findings do not support the mainstream of epidemiological findings, derived from samples more heterogeneous in age, sociodemographic characteristics, and health, suggesting that poor sleep is associated with an unhealthy cardiovascular phenotype.
Authors:
Silja Martikainen; Anu-Katriina Pesonen; Kimmo Feldt; Alexander Jones; Jari Lahti; Riikka Pyhälä; Kati Heinonen; Eero Kajantie; Johan Eriksson; Katri Räikkönen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-9
Journal Detail:
Title:  Hypertension     Volume:  -     ISSN:  1524-4563     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute of Behavioural Sciences, Institute of Clinical Medicine, Hospital for Children and Adolescent, and Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland; University College London Institute of Cardiovascular Science, London, United Kingdom; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland; Unit of General Practice and Folkhälsan Research Center, Helsinki University Central Hospital, Helsinki, Finland; Vasa Central Hospital, Vasa, Finland.
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