| Pooled intravenous immunoglobulin in the management of systemic vasculitis. | |
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MedLine Citation:
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PMID: 8296659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Investigation into the therapeutic use of intravenous immunoglobulin (IVIg) in systemic vasculitis was prompted by the detection of anti-idiotype antibodies reactive with ANCA in IVIg and the proven ability of IVIg to reduce the incidence of coronary artery aneurysms in Kawasaki disease. The efficacy and safety of IVIg (Sandoglobulin) was assessed in an open study of 26 patients with active systemic vasculitis. Eight weeks after IVIg 13 patients were in full and 13 in partial remission, clinical benefit was maintained in 18 twelve months later and was reflected by changes in C-reactive protein and ANCA. |
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Authors:
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D R Jayne; C M Lockwood |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 336 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1993 |
Date Detail:
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Created Date: 1994-03-03 Completed Date: 1994-03-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 469-72 Citation Subset: IM |
Affiliation:
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Department of Medicine, School of Clinical Medicine, University of Cambridge, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Antineutrophil Cytoplasmic Autoantibodies / blood Blood Sedimentation C-Reactive Protein / metabolism Cyclophosphamide / therapeutic use Female Humans Immunoglobulin G / blood Immunoglobulins, Intravenous / therapeutic use* Middle Aged Prednisolone / therapeutic use Vasculitis / immunology, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antineutrophil Cytoplasmic; 0/Autoantibodies; 0/Immunoglobulin G; 0/Immunoglobulins, Intravenous; 50-18-0/Cyclophosphamide; 50-24-8/Prednisolone; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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